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CAF4 Caf4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853908, updated on 5-Jan-2025

Summary

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Official Symbol
CAF4
Official Full Name
Caf4p
Primary source
SGD:S000001744
Locus tag
YKR036C
See related
AllianceGenome:SGD:S000001744; FungiDB:YKR036C; VEuPathDB:YKR036C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in mitochondrial fission; peroxisome fission; and regulation of transcription by RNA polymerase II. Located in mitochondrion. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See CAF4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (508702..510633, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Dal80p Neighboring gene Did2p Neighboring gene Spc34p Neighboring gene tRNA N6-adenosine threonylcarbamoyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The mitochondrial fission adaptors Caf4 and Mdv1 are not functionally equivalent. Guo Q, et al. PLoS One, 2012. PMID 23300936, Free PMC Article
  2. Peroxisome fission in Hansenula polymorpha requires Mdv1 and Fis1, two proteins also involved in mitochondrial fission. Nagotu S, et al. Traffic, 2008 Sep. PMID 18513378
  3. Structural basis for recruitment of mitochondrial fission complexes by Fis1. Zhang Y, et al. Proc Natl Acad Sci U S A, 2007 Nov 20. PMID 17998537, Free PMC Article
  4. Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface. Schauss AC, et al. J Cell Sci, 2006 Aug 1. PMID 16835275
  5. Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes. Koirala S, et al. J Cell Biol, 2010 Dec 13. PMID 21149566, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p; association of Caf4p and Mdv1p with peroxisomes relies on Fis1p
    Title: Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p.
  2. Mdv1p and Caf4p are molecular adaptors that recruit Dnm1p to mitochondrial fission sites.
    Title: The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondria.
  3. Data suggest that Caf4p and Fis1, but not Mdv1, play a role in determining the polarized localization of those Dnm1p clusters that are not immediately involved in the mitochondrial fission process.
    Title: Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in mitochondrial fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial fission IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial fission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial fission IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in peroxisome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peroxisome fission IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of CCR4-NOT complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Caf4p
NP_012962.3
  • WD40 repeat-containing protein associated with the CCR4-NOT complex; interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission; CAF4 has a paralog, MDV1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    508702..510633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179826.2 → NP_012962.3  TPA: Caf4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012962.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZZZ8, D6VX99, P36130
    UniProtKB/TrEMBL
    C8ZCK1, G2WI66, N1P829
    Conserved Domains (3) summary
    cd00200
    Location:318 → 641
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:322 → 360
    7WD40; WD40 repeat [structural motif]
    pfam11615
    Location:65 → 124
    Caf4; CCR4-associated factor 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36130.3

Gene LinkOut

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