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ECM4 S-glutathionyl-(chloro)hydroquinone reductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 853951, updated on 9-Dec-2024

Summary

Official Symbol
ECM4
Official Full Name
S-glutathionyl-(chloro)hydroquinone reductase
Primary source
SGD:S000001784
Locus tag
YKR076W
See related
AllianceGenome:SGD:S000001784; FungiDB:YKR076W; VEuPathDB:YKR076W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
GTO2
Summary
Enables glutathione transferase activity. Involved in glutathione metabolic process. Located in cytoplasm. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See ECM4 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (582283..583395)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Aim29p Neighboring gene uncharacterized protein Neighboring gene Msa2p Neighboring gene sorting nexin family protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables glutathione dehydrogenase (ascorbate) activity IEA
Inferred from Electronic Annotation
more info
 
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in glutathione metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
S-glutathionyl-(chloro)hydroquinone reductase
NP_013002.3
  • S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR); glutathione transferase involved in cell-surface biosynthesis and architecture; catalyzes glutathione (GSH)-dependent reduction of GS-trichloro-p-hydroquinone to trichloro-p-hydroquinone; expression upregulated upon exposure to genotoxic agents, such as methyl methanesulfonate, cisplatin and bleomycin; not an essential gene; similar to YGR154C; green fluorescent protein (GFP)-fusion protein localizes to cytoplasm

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    582283..583395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179866.3NP_013002.3  TPA: S-glutathionyl-(chloro)hydroquinone reductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013002.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXD6, P36156
    UniProtKB/TrEMBL
    A7A035, B3LRF0, C7GXD4, C8ZCN7, G2WIA3
    Conserved Domains (1) summary
    COG0435
    Location:1370
    ECM4; Glutathionyl-hydroquinone reductase [Energy production and conversion]