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SRP40 Srp40p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853967, updated on 4-Jan-2025

Summary

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Official Symbol
SRP40
Official Full Name
Srp40p
Primary source
SGD:S000001800
Locus tag
YKR092C
See related
AllianceGenome:SGD:S000001800; FungiDB:YKR092C; VEuPathDB:YKR092C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to be involved in nucleocytoplasmic transport. Located in nucleolus. Orthologous to human NOLC1 (nucleolar and coiled-body phosphoprotein 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SRP40 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (612665..613885, complement)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Pxl1p Neighboring gene DNA-binding protein SRL3 Neighboring gene Ptr2p Neighboring gene ubiquitin-ribosomal 60S subunit protein L40B fusion protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative splicing in exon 9 of glucocorticoid receptor pre-mRNA is regulated by SRp40. Yan XB, et al. Mol Biol Rep, 2010 Mar. PMID 19343537
  2. Comparison of the rat nucleolar protein nopp140 with its yeast homolog SRP40. Differential phosphorylation in vertebrates and yeast. Meier UT. J Biol Chem, 1996 Aug 9. PMID 8702624
  3. The Srp40 protein plays a dose-sensitive role in preribosome assembly or transport and depends on its carboxy-terminal domain for proper localization to the yeast nucleoskeleton. Ikonomova R, et al. DNA Cell Biol, 1997 Oct. PMID 9364927
  4. Interactions between three common subunits of yeast RNA polymerases I and III. Lalo D, et al. Proc Natl Acad Sci U S A, 1993 Jun 15. PMID 8516295, Free PMC Article
  5. Genetic interaction between a chaperone of small nucleolar ribonucleoprotein particles and cytosolic serine hydroxymethyltransferase. Yang Y, et al. J Biol Chem, 2003 Jun 27. PMID 12700234

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in nucleocytoplasmic transport ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Srp40p
NP_013018.3
  • Nucleolar serine-rich protein; role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    612665..613885 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179882.3 → NP_013018.3  TPA: Srp40p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013018.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXF2, P32583
    Conserved Domains (1) summary
    pfam05022
    Location:334 → 404
    SRP40_C; SRP40, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32583.2

Gene LinkOut

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