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ESL2 Esl2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 853971, updated on 9-Dec-2024

Summary

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Official Symbol
ESL2
Official Full Name
Esl2p
Primary source
SGD:S000001804
Locus tag
YKR096W
See related
AllianceGenome:SGD:S000001804; FungiDB:YKR096W; VEuPathDB:YKR096W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable telomerase RNA binding activity and telomeric DNA binding activity. Predicted to be involved in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Located in peroxisome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ESL2 in Genome Data Viewer
Location:
chromosome: XI
Exon count:
1
Sequence:
Chromosome: XI; NC_001143.9 (626793..630380)

Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Mlp1p Neighboring gene chromatin DNA-binding EKC/KEOPS complex subunit PCC1 Neighboring gene phosphoenolpyruvate carboxykinase PCK1 Neighboring gene ubiquitin-specific protease UBP11

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PINc domain protein Utp24, a putative nuclease, is required for the early cleavage steps in 18S rRNA maturation. Bleichert F, et al. Proc Natl Acad Sci U S A, 2006 Jun 20. PMID 16769905, Free PMC Article
  2. Genetic suppressors of Δgrx3 Δgrx4, lacking redundant multidomain monothiol yeast glutaredoxins, rescue growth and iron homeostasis. Li G, et al. Biosci Rep, 2022 Jun 30. PMID 35593209, Free PMC Article
  3. Monopolar attachment of sister kinetochores at meiosis I requires casein kinase 1. Petronczki M, et al. Cell, 2006 Sep 22. PMID 16990132
  4. Uptake of inorganic phosphate is a limiting factor for Saccharomyces cerevisiae during growth at low temperatures. Vicent I, et al. FEMS Yeast Res, 2015 May. PMID 25725023
  5. Yeast hEST1A/B (SMG5/6)-like proteins contribute to environment-sensing adaptive gene expression responses. Lai X, et al. G3 (Bethesda), 2013 Oct 3. PMID 23893744, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Esl2 has no telomere-related functions, but contributes to the regulation of adaptive gene expression responses.
    Title: Yeast hEST1A/B (SMG5/6)-like proteins contribute to environment-sensing adaptive gene expression responses.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables telomerase RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables telomeric DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
part_of telomerase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Esl2p
NP_013022.1
  • hEST1A/B (SMG5/6)-like protein; contributes to environment-sensing adaptive gene expression responses; Esl2p and Esl1p contain a 14-3-3-like domain and a putative PilT N-terminus ribonuclease domain; interacts with Pex14p; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; ESL2 has a paralog, ESL1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001143.9 Reference assembly

    Range
    626793..630380
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179886.1 → NP_013022.1  TPA: Esl2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013022.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VXF7, P36168
    UniProtKB/TrEMBL
    N1P876
    Conserved Domains (1) summary
    cl28905
    Location:1027 → 1159
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36168.1

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