BAS1 Bas1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: BAS1
Official Full Name: Bas1p
Primary source: SGD:S000001807
Locus tag: YKR099W
See related: AllianceGenome:SGD:S000001807; FungiDB:YKR099W; VEuPathDB:YKR099W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to several human genes including MYBL1 (MYB proto-oncogene like 1); MYBL2 (MYB proto-oncogene like 2); and MYB (MYB proto-oncogene, transcription factor). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See BAS1 in Genome Data Viewer

Location:: chromosome: XI

Exon count:: 1

Sequence:: Chromosome: XI; NC_001143.9 (635851..638286)

Chromosome XI - NC_001143.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001143.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Histone Deacetylases Hst1 and Rpd3 Integrate De Novo NAD[+] Metabolism with Phosphate Sensing in Saccharomyces cerevisiae.
Title: The Histone Deacetylases Hst1 and Rpd3 Integrate De Novo NAD(+) Metabolism with Phosphate Sensing in Saccharomyces cerevisiae.
We examined fine-scale DSB distributions in TF mutant strains by deep sequencing oligonucleotides that remain covalently bound to Spo11 as a byproduct of DSB formation, mapped Bas1 and Ino4 binding sites in meiotic cells
Title: High-Resolution Global Analysis of the Influences of Bas1 and Ino4 Transcription Factors on Meiotic DNA Break Distributions in Saccharomyces cerevisiae.
From the experimental data it was inferred that the transcription factors Bas1p, Pho2p, and Gcn4p play a central role in the regulatory events causing the Crabtree effect in Saccharomyces cerevisiae.
Title: Gcn4p and the Crabtree effect of yeast: drawing the causal model of the Crabtree effect in Saccharomyces cerevisiae and explaining evolutionary trade-offs of adaptation to galactose through systems biology.
Gcn4p is responsible for the basal and inducible expression of the ADE3 gene, while Bas1p is required for its basal expression.
Title: Cooperative regulation of ADE3 transcription by Gcn4p and Bas1p in Saccharomyces cerevisiae.
Gcn4p and Bas1p transcriptional regulators have essential roles during adaptation to anaerobic growth of Saccharomyces cerevisiae
Title: Essential role of one-carbon metabolism and Gcn4p and Bas1p transcriptional regulators during adaptation to anaerobic growth of Saccharomyces cerevisiae.
The recombination activities of some genes with Bas1p binding sites during meiosis were dependent on Bas1p.
Title: Global analysis of the relationship between the binding of the Bas1p transcription factor and meiosis-specific double-strand DNA breaks in Saccharomyces cerevisiae.
glycine affects Bas1p activation of transcription rather than DNA binding
Title: Transcriptional regulation of the one-carbon metabolism regulon in Saccharomyces cerevisiae by Bas1p.
Data show that Bas1 is localized to the nucleus under both repressing and derepressing conditions, and that Pho2 is not required for the association of Bas1 with chromosomal DNA.
Title: DNA-bound Bas1 recruits Pho2 to activate ADE genes in Saccharomyces cerevisiae.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Bas1p

NP_013025.3

Myb-related transcription factor; involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; controls cellular ATP levels; also involved in regulation of meiotic recombination at specific genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001143.9 Reference assembly

Range

635851..638286

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179889.3 → NP_013025.3 TPA: Bas1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013025.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VXG0, P22035

UniProtKB/TrEMBL

A7A059, B3LRH4

Conserved Domains (1) summary

COG5147
Location:17 → 585

REB1; Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning]