U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

RPL25 ribosomal 60S subunit protein L25 [ Saccharomyces cerevisiae S288C ]

Gene ID: 853993, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
RPL25
Official Full Name
ribosomal 60S subunit protein L25
Primary source
SGD:S000005487
Locus tag
YOL127W
See related
AllianceGenome:SGD:S000005487; FungiDB:YOL127W; VEuPathDB:YOL127W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables RNA binding activity. Involved in ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit and preribosome, large subunit precursor. Orthologous to human RPL23A (ribosomal protein L23a). [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See RPL25 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
2
Sequence:
Chromosome: XV; NC_001147.6 (80348..81190)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Vps68p Neighboring gene serine/threonine protein kinase YGK3 Neighboring gene malate dehydrogenase MDH2 Neighboring gene tRNA:m4X modification enzyme

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and functional analysis of the nuclear localization signals of ribosomal protein L25 from Saccharomyces cerevisiae. Schaap PJ, et al. J Mol Biol, 1991 Sep 5. PMID 1920406
  2. Domain III of Saccharomyces cerevisiae 25 S ribosomal RNA: its role in binding of ribosomal protein L25 and 60 S subunit formation. van Beekvelt CA, et al. J Mol Biol, 2000 Feb 11. PMID 10656814
  3. Mutational analysis of the C-terminal region of Saccharomyces cerevisiae ribosomal protein L25 in vitro and in vivo demonstrates the presence of two distinct functional elements. Kooi EA, et al. J Mol Biol, 1994 Jul 15. PMID 8028007
  4. Structural comparison of yeast ribosomal protein genes. Leer RJ, et al. Nucleic Acids Res, 1984 Sep 11. PMID 6091033, Free PMC Article
  5. Yeast ribosomal protein L25 binds to an evolutionary conserved site on yeast 26S and E. coli 23S rRNA. el-Baradi TT, et al. EMBO J, 1985 Aug. PMID 3905389, Free PMC Article

See all (171) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rpl25p plays a critical role in the recruitment of SRP to the ribosome
    Title: Access to ribosomal protein Rpl25p by the signal recognition particle is required for efficient cotranslational translocation.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IC
Inferred by Curator
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
 PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of preribosome, large subunit precursor IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ribosomal 60S subunit protein L25
NP_014514.1
  • Ribosomal 60S subunit protein L25; primary rRNA-binding ribosomal protein component of large ribosomal subunit; binds to 25S rRNA via a conserved C-terminal motif; homologous to mammalian ribosomal protein L23A and bacterial L23

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    80348..81190
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183381.1 → NP_014514.1  TPA: ribosomal 60S subunit protein L25 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014514.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1U1, P04456
    UniProtKB/TrEMBL
    A6ZN84, B3LIT9, C8ZHI9, G2WMB0, N1P3G5
    Conserved Domains (1) summary
    PTZ00191
    Location:20 → 142
    PTZ00191; 60S ribosomal protein L23a; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04456.4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous