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PTH4 Pth4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854035, updated on 9-Dec-2024

Summary

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Official Symbol
PTH4
Official Full Name
Pth4p
Primary source
SGD:S000005474
Locus tag
YOL114C
See related
AllianceGenome:SGD:S000005474; FungiDB:YOL114C; VEuPathDB:YOL114C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables aminoacyl-tRNA hydrolase activity. Involved in mitochondrial translation. Part of mitochondrial large ribosomal subunit. Orthologous to human MRPL58 (mitochondrial ribosomal protein L58). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PTH4 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (103317..103925, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Msn1p Neighboring gene non-canonical poly(A) polymerase PAP2 Neighboring gene putative serine/threonine protein kinase SKM1 Neighboring gene Rab GTPase-activating protein MSB4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A stalled-ribosome rescue factor Pth3 is required for mitochondrial translation against antibiotics in Saccharomyces cerevisiae. Hoshino S, et al. Commun Biol, 2021 Mar 8. PMID 33686140, Free PMC Article
  2. Proteomic profiling of the mitochondrial ribosome identifies Atp25 as a composite mitochondrial precursor protein. Woellhaf MW, et al. Mol Biol Cell, 2016 Oct 15. PMID 27582385, Free PMC Article
  3. Organization of Mitochondrial Gene Expression in Two Distinct Ribosome-Containing Assemblies. Kehrein K, et al. Cell Rep, 2015 Feb 17. PMID 25683707
  4. Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Balakrishnan R, et al. Nucleic Acids Res, 2005 Jan 1. PMID 15608219, Free PMC Article
  5. A genetic screen for high copy number suppressors of the synthetic lethality between elg1Δ and srs2Δ in yeast. Gazy I, et al. G3 (Bethesda), 2013 May 20. PMID 23704284, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables aminoacyl-tRNA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables aminoacyl-tRNA hydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables translation release factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation release factor activity, codon nonspecific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translation IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitochondrial translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational termination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pth4p
NP_014527.1
  • Stalled-ribosome rescue factor srRF1; similar to human peptidyl-tRNA hydrolase ICT1; associates with mitochondrial large subunit; not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    103317..103925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183368.1 → NP_014527.1  TPA: Pth4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014527.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1V3, Q12322
    UniProtKB/TrEMBL
    A6ZN96, B3LIV1, B5VRE2, C7GSS2, C8ZHK1, G2WMC2, N1NX23
    Conserved Domains (1) summary
    COG1186
    Location:1 → 200
    PrfB; Protein chain release factor B [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12322.1

Gene LinkOut

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