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MPD2 protein disulfide isomerase MPD2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854065, updated on 9-Dec-2024

Summary

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Official Symbol
MPD2
Official Full Name
protein disulfide isomerase MPD2
Primary source
SGD:S000005448
Locus tag
YOL088C
See related
AllianceGenome:SGD:S000005448; FungiDB:YOL088C; VEuPathDB:YOL088C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein disulfide isomerase activity and protein-disulfide reductase activity. Involved in protein folding. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MPD2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (153912..154745, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene mismatch repair ATPase MSH2 Neighboring gene Hal9p Neighboring gene Duf1p Neighboring gene Mhf1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner. Tachikawa H, et al. Biochem Biophys Res Commun, 1997 Oct 29. PMID 9367834
  2. Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum. Frand AR, et al. Mol Cell, 1999 Oct. PMID 10549279
  3. Functional differences between human and yeast protein disulfide isomerase family proteins. Kimura T, et al. Biochem Biophys Res Commun, 2004 Jul 23. PMID 15219835
  4. Functional differences in yeast protein disulfide isomerases. Nørgaard P, et al. J Cell Biol, 2001 Feb 5. PMID 11157982, Free PMC Article
  5. Gene regulation in response to protein disulphide isomerase deficiency. Nørgaard P, et al. Yeast, 2003 May. PMID 12734802

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein disulfide isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein disulfide isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein disulfide isomerase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein disulfide isomerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein disulfide isomerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-disulfide reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-disulfide reductase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein-disulfide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IGI
Inferred from Genetic Interaction
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein disulfide isomerase MPD2
NP_014553.1
  • Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    153912..154745 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183342.1 → NP_014553.1  TPA: protein disulfide isomerase MPD2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014553.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W1Y0, Q99316
    UniProtKB/TrEMBL
    C7GRU1, G2WME7, N1NX63
    Conserved Domains (1) summary
    cl00388
    Location:48 → 170
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99316.1

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