PLB3 lysophospholipase [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: PLB3
Official Full Name: lysophospholipase
Primary source: SGD:S000005371
Locus tag: YOL011W
See related: AllianceGenome:SGD:S000005371; FungiDB:YOL011W; VEuPathDB:YOL011W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables lysophospholipase activity. Involved in phosphatidylinositol metabolic process and phosphatidylserine catabolic process. Located in extracellular region. Orthologous to several human genes including PLA2G4C (phospholipase A2 group IVC) and PLA2G4F (phospholipase A2 group IVF). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	IEA Inferred from Electronic Annotation more info
enables lysophospholipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in glycerophospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylserine catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylserine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole	HDA more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

NP_014632.1

Phospholipase B (lysophospholipase) involved in lipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro; PLB3 has a paralog, PLB1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain