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SLG1 Slg1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854170, updated on 9-Dec-2024

Summary

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Official Symbol
SLG1
Official Full Name
Slg1p
Primary source
SGD:S000005534
Locus tag
YOR008C
See related
AllianceGenome:SGD:S000005534; FungiDB:YOR008C; VEuPathDB:YOR008C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HCS77; WSC1
Summary
Enables transmembrane signaling receptor activity. Involved in several processes, including Rho protein signal transduction; fungal-type cell wall organization; and pexophagy. Located in cellular bud neck and plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SLG1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (341278..342414, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Sgt2p Neighboring gene tRNA-Arg Neighboring gene uncharacterized protein Neighboring gene Tir4p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. WSC-1 and HAM-7 are MAK-1 MAP kinase pathway sensors required for cell wall integrity and hyphal fusion in Neurospora crassa. Maddi A, et al. PLoS One, 2012. PMID 22879952, Free PMC Article
  2. Characterization of sensor-specific stress response by transcriptional profiling of wsc1 and mid2 deletion strains and chimeric sensors in Saccharomyces cerevisiae. Bermejo C, et al. OMICS, 2010 Dec. PMID 20958245
  3. Single-molecule atomic force microscopy reveals clustering of the yeast plasma-membrane sensor Wsc1. Heinisch JJ, et al. PLoS One, 2010 Jun 14. PMID 20559440, Free PMC Article
  4. Measurement of the mechanical behavior of yeast membrane sensors using single-molecule atomic force microscopy. Heinisch JJ, et al. Nat Protoc, 2010 Apr. PMID 20360762
  5. A Three-Dimensional Model of the Yeast Transmembrane Sensor Wsc1 Obtained by SMA-Based Detergent-Free Purification and Transmission Electron Microscopy. Voskoboynikova N, et al. J Fungi (Basel), 2021 Feb 5. PMID 33562593, Free PMC Article

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The sensors Wsc1 and Mid2 reside in different plasma membrane compartments in Saccharomyces cerevisiae.
    Title: Yeast cell wall integrity sensors form specific plasma membrane microdomains important for signalling.
  2. wsc1 mutation disrupted biofilm formation in a Flo11p-independent manner.
    Title: The Wsc1p cell wall signaling protein controls biofilm (Mat) formation independently of Flo11p in Saccharomyces cerevisiae.
  3. Study indicates an important role of the extracellular domain of Wsc1 in mediating signal specificity of this sensor to detect cell wall damage.
    Title: Characterization of sensor-specific stress response by transcriptional profiling of wsc1 and mid2 deletion strains and chimeric sensors in Saccharomyces cerevisiae.
  4. Data show that Wsc1 uses a clathrin-dependent NPFDD signal, Wsc2 relies on a specific lysine residue (K495).
    Title: A block of endocytosis of the yeast cell wall integrity sensors Wsc1 and Wsc2 results in reduced fitness in vivo.
  5. endoplasmic reticulum surveillance evasion makes Wsc1p an obligate substrate of Golgi quality control
    Title: Evasion of endoplasmic reticulum surveillance makes Wsc1p an obligate substrate of Golgi quality control.
  6. Chimers of Wsc1 fused to GFP have been employed to show that intracellular and membrane distribution is only dependent on a membrane-anchored cytoplasmic tail.
    Title: Functional analyses of the extra- and intracellular domains of the yeast cell wall integrity sensors Mid2 and Wsc1.
  7. WSC1 is involved in reorganization of the actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae.
    Title: The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae.
  8. Participates in the regulation of a Rho3/4-dependent cellular mechanism, and this is distinct from the role of Wsc1p in the PKC-MAP kinase pathway.
    Title: The Rho3 and Rho4 small GTPases interact functionally with Wsc1p, a cell surface sensor of the protein kinase C cell-integrity pathway in Saccharomyces cerevisiae.
  9. The dynamic localization of Wsc1p, a sensor of the extracellular wall in yeast, resembles polarized distribution of certain extracellular matrix-sensing integrins through endocytic recycling.
    Title: NPFXD-mediated endocytosis is required for polarity and function of a yeast cell wall stress sensor.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell wall organization IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of cell polarity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fungal-type cell wall organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pexophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to osmotic stress IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cellular bud IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cellular bud neck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in mating projection tip HDA PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Slg1p
NP_014650.1
  • Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    341278..342414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183427.1 → NP_014650.1  TPA: Slg1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014650.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W274, P54867
    UniProtKB/TrEMBL
    A6ZNL3, B3LJ63, C7GJU5, C8ZHX1, G2WMN8, N1NWF2
    Conserved Domains (1) summary
    smart00321
    Location:22 → 110
    WSC; present in yeast cell wall integrity and stress response component proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54867.1

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