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ROD1 Rod1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854183, updated on 4-Jan-2025

Summary

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Official Symbol
ROD1
Official Full Name
Rod1p
Primary source
SGD:S000005544
Locus tag
YOR018W
See related
AllianceGenome:SGD:S000005544; FungiDB:YOR018W; VEuPathDB:YOR018W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ART4
Summary
Enables ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of receptor internalization; and ubiquitin-dependent endocytosis. Located in plasma membrane. Orthologous to several human genes including ARRDC1 (arrestin domain containing 1); ARRDC2 (arrestin domain containing 2); and ARRDC3 (arrestin domain containing 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ROD1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (364369..366882)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Erp4p Neighboring gene Pet127p Neighboring gene uncharacterized protein Neighboring gene Hsp10p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ROD1, a novel gene conferring multiple resistance phenotypes in Saccharomyces cerevisiae. Wu AL, et al. J Biol Chem, 1996 Feb 9. PMID 8621680
  2. Rod1, an arrestin-related protein, is phosphorylated by Snf1-kinase in Saccharomyces cerevisiae. Shinoda J, et al. Biochem Biophys Res Commun, 2007 Dec 14. PMID 17949685
  3. 2-deoxyglucose transiently inhibits yeast AMPK signaling and triggers glucose transporter endocytosis, potentiating the drug toxicity. Laussel C, et al. PLoS Genet, 2022 Aug. PMID 35951639, Free PMC Article
  4. The C-terminal region of the yeast monocarboxylate transporter Jen1 acts as a glucose signal-responding degron recognized by the α-arrestin Rod1. Fujita S, et al. J Biol Chem, 2018 Jul 13. PMID 29789424, Free PMC Article
  5. Glucose-induced internalization of the S. cerevisiae galactose permease Gal2 is dependent on phosphorylation and ubiquitination of its aminoterminal cytoplasmic tail. Tamayo Rojas SA, et al. FEMS Yeast Res, 2021 Apr 7. PMID 33791789

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. demonstrated the interaction of Rod1 with Hxt6 and showed that the localization of the Rod1-Hxt6 complex at the plasma membrane is affected by carbon source and is reduced upon overexpression of SNF1 and BMH2
    Title: Regulation of the Yeast Hxt6 Hexose Transporter by the Rod1 α-Arrestin, the Snf1 Protein Kinase, and the Bmh2 14-3-3 Protein.
  2. Evidence prove that Ldb19 and Rod1 recruit Rsp5 to Ste2 for its internalization.
    Title: Specific α-arrestins negatively regulate Saccharomyces cerevisiae pheromone response by down-modulating the G-protein-coupled receptor Ste2.
  3. Rod1 relays glucose signaling to transporter endocytosis and provides the first molecular insights into the nutrient-induced activation of an arrestin-related protein through a switch in post-translational modifications.
    Title: A molecular switch on an arrestin-like protein relays glucose signaling to transporter endocytosis.
  4. Rod1 protein was directly phosphorylated by Snf1-kinase in vitro. The substitution of the serine residue 447 to alanine slightly enhanced the resistance to the drug.
    Title: Rod1, an arrestin-related protein, is phosphorylated by Snf1-kinase in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of receptor internalization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent endocytosis ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rod1p
NP_014661.1
  • Alpha-arrestin involved in ubiquitin-dependent endocytosis; activating dephosphorylation relays glucose signaling to transporter endocytosis; calcineurin dephosphorylation is required for Rsp5p-dependent internalization of agonist-occupied Ste2p, as part of signal desensitization; recruits Rsp5p to Ste2p via its 2 PPXY motifs; protein abundance increases in response to DNA replication stress; ROD1 has a paralog, ROG3, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    364369..366882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183437.1 → NP_014661.1  TPA: Rod1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014661.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W284, Q02805, Q12475
    UniProtKB/TrEMBL
    A6ZNM2
    Conserved Domains (2) summary
    smart01017
    Location:232 → 395
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:157 → 215
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02805.1

Gene LinkOut

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