U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

BUB3 Bub3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854191, updated on 9-Dec-2024

Summary

Official Symbol
BUB3
Official Full Name
Bub3p
Primary source
SGD:S000005552
Locus tag
YOR026W
See related
AllianceGenome:SGD:S000005552; FungiDB:YOR026W; VEuPathDB:YOR026W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
PAC9
Summary
Enables ubiquitin binding activity. Involved in mitotic DNA integrity checkpoint signaling and positive regulation of protein autoubiquitination. Located in kinetochore. Part of mitotic checkpoint complex. Orthologous to human BUB3 (BUB3 mitotic checkpoint protein). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See BUB3 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (379781..380806)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ahc1p Neighboring gene NAD-dependent histone deacetylase HST3 Neighboring gene Hsp90 cochaperone STI1 Neighboring gene Cin5p

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of bub1-bub3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
located_in kinetochore IEA
Inferred from Electronic Annotation
more info
 
part_of mitotic checkpoint complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of mitotic checkpoint complex IPI
Inferred from Physical Interaction
more info
PubMed 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Bub3p
NP_014669.1
  • Kinetochore checkpoint WD40 repeat protein; localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p; functions at kinetochore to activate APC/C-Cdc20p for normal mitotic progression

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    379781..380806
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183445.1NP_014669.1  TPA: Bub3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014669.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W292, P26449
    UniProtKB/TrEMBL
    G2WMQ7
    Conserved Domains (2) summary
    COG2319
    Location:2317
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1455
    7WD40; WD40 repeat [structural motif]