U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CIN5 Cin5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854193, updated on 4-Jan-2025

Summary

Go to the top of the page Help
Official Symbol
CIN5
Official Full Name
Cin5p
Primary source
SGD:S000005554
Locus tag
YOR028C
See related
AllianceGenome:SGD:S000005554; FungiDB:YOR028C; VEuPathDB:YOR028C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
HAL6; YAP4
Summary
Enables DNA-binding transcription factor binding activity and sequence-specific DNA binding activity. Involved in hyperosmotic salinity response and response to xenobiotic stimulus. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jan 2025]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See CIN5 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (383533..384420, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Bub3p Neighboring gene Hsp90 cochaperone STI1 Neighboring gene uncharacterized protein Neighboring gene Dfg16p

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Transcriptional response of Saccharomyces cerevisiae to the plasma membrane-perturbing compound chitosan. Zakrzewska A, et al. Eukaryot Cell, 2005 Apr. PMID 15821130, Free PMC Article
  2. Two nuclear proteins, Cin5 and Ydr259c, confer resistance to cisplatin in Saccharomyces cerevisiae. Furuchi T, et al. Mol Pharmacol, 2001 Mar. PMID 11179441
  3. Coevolution within a transcriptional network by compensatory trans and cis mutations. Kuo D, et al. Genome Res, 2010 Dec. PMID 20978140, Free PMC Article
  4. Quinone reductase acts as a redox switch of the 20S yeast proteasome. Sollner S, et al. EMBO Rep, 2009 Jan. PMID 19029946, Free PMC Article
  5. Expression of YAP4 in Saccharomyces cerevisiae under osmotic stress. Nevitt T, et al. Biochem J, 2004 Apr 15. PMID 14680476, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutant forms of Yap1 that are constitutively trapped in the nucleus are degraded in the absence of an oxidant signal
    Title: Proteolytic degradation of the Yap1 transcription factor is regulated by subcellular localization and the E3 ubiquitin ligase Not4.
  2. Yap4 activity is maintained in the absence of phosphorylation. However, this modification seems to be required for stability of the protein, as the non-phosphorylated form has a shorter half-life than the phosphorylated one.
    Title: Yap4 PKA- and GSK3-dependent phosphorylation affects its stability but not its nuclear localization.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables sequence-specific DNA binding HDA PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hyperosmotic response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hyperosmotic salinity response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Cin5p
NP_014671.1
  • Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative stress and sequestered in the cytoplasm by Lot6p under reducing conditions; CIN5 has a paralog, YAP6, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    383533..384420 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183447.1 → NP_014671.1  TPA: Cin5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014671.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W294, P40917
    UniProtKB/TrEMBL
    A6ZNN2, B3LJ82, B5VRT0, C7GLF8, G2WMQ9
    Conserved Domains (2) summary
    cd14688
    Location:240 → 291
    bZIP_YAP; coiled coil [structural motif]
    pfam00170
    Location:239 → 294
    bZIP_1; bZIP transcription factor
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40917.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools