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CYC2 oxidoreductase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854202, updated on 9-Dec-2024

Summary

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Official Symbol
CYC2
Official Full Name
oxidoreductase
Primary source
SGD:S000005563
Locus tag
YOR037W
See related
AllianceGenome:SGD:S000005563; FungiDB:YOR037W; VEuPathDB:YOR037W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables oxidoreductase activity. Involved in cytochrome c-heme linkage and mitochondrial membrane organization. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CYC2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (401555..402655)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene She4p Neighboring gene SNAP receptor PEP12 Neighboring gene Hir2p Neighboring gene casein kinase 2 regulatory subunit CKB2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast cytochrome c-specific protein-lysine methyltransferase: coordinate regulation with cytochrome c and activities in cyc mutants. Liao HN, et al. J Bacteriol, 1979 Jun. PMID 222727, Free PMC Article
  2. CYC2 encodes a factor involved in mitochondrial import of yeast cytochrome c. Dumont ME, et al. Mol Cell Biol, 1993 Oct. PMID 8413243, Free PMC Article
  3. Cyc2p is required for maintaining ionic stability and efficient cytochrome c import and mitochondrial function in Saccharomyces cerevisiae. Pearce DA, et al. FEBS Lett, 1998 Nov 20. PMID 9845343
  4. The flavoprotein Cyc2p, a mitochondrial cytochrome c assembly factor, is a NAD(P)H-dependent haem reductase. Corvest V, et al. Mol Microbiol, 2012 Mar. PMID 22257001
  5. Requirements of Cyc2p and the porin, Por1p, for ionic stability and mitochondrial integrity in Saccharomyces cerevisiae. Sánchez NS, et al. Arch Biochem Biophys, 2001 Aug 15. PMID 11488609

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyc2p catalyses the NAD(P)H-dependent reduction of hemin, and interacts with CCHL and apoforms of cytochrome c and c1.
    Title: The flavoprotein Cyc2p, a mitochondrial cytochrome c assembly factor, is a NAD(P)H-dependent haem reductase.
  2. in vivo, Cyc2p interacts with cytochrome c heme lyase and is involved in the reduction of heme prior to its ligation to apocytochrome c by CCHL
    Title: Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables oxidoreductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytochrome c-heme linkage IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in mitochondrial membrane organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
oxidoreductase
NP_014680.2
  • Mitochondrial peripheral inner membrane protein; contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p)

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    401555..402655
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183456.1 → NP_014680.2  TPA: oxidoreductase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014680.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2A4, P38909
    UniProtKB/TrEMBL
    A6ZNP2, B3LJ90, C7GLG6, C8ZHZ9, N1P2Y8
    Conserved Domains (1) summary
    cd06183
    Location:68 → 365
    cyt_b5_reduct_like; Cytochrome b5 reductase catalyzes the reduction of 2 molecules of cytochrome b5 using NADH as an electron donor. Like ferredoxin reductases, these proteins have an N-terminal FAD binding subdomain and a C-terminal NADH binding subdomain, separated by a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38909.3

Gene LinkOut

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