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SLD7 Sld7p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854226, updated on 9-Dec-2024

Summary

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Official Symbol
SLD7
Official Full Name
Sld7p
Primary source
SGD:S000005586
Locus tag
YOR060C
See related
AllianceGenome:SGD:S000005586; FungiDB:YOR060C; VEuPathDB:YOR060C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YOR29-11
Summary
Involved in regulation of DNA-templated DNA replication initiation. Located in chromosome, centromeric region. Part of DNA replication preinitiation complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SLD7 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (440390..441163, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene putative hydrolase Neighboring gene casein kinase 2 catalytic subunit CKA2 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiomics Approach to Novel Therapeutic Targets for Cancer and Aging-Related Diseases: Role of Sld7 in Yeast Aging Network. Dayan IE, et al. OMICS, 2017 Feb. PMID 28118095
  2. A low cost PS based microfluidic platform to investigate cell cycle towards developing a therapeutic strategy for cancer. Odabasi IE, et al. Biomed Microdevices, 2018 Jul 5. PMID 29974243
  3. Role of essential genes in mitochondrial morphogenesis in Saccharomyces cerevisiae. Altmann K, et al. Mol Biol Cell, 2005 Nov. PMID 16135527, Free PMC Article
  4. The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3. Itou H, et al. Acta Crystallogr D Biol Crystallogr, 2015 Aug. PMID 26249346
  5. Origin association of Sld3, Sld7, and Cdc45 proteins is a key step for determination of origin-firing timing. Tanaka S, et al. Curr Biol, 2011 Dec 20. PMID 22169533

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Here, the crystal structure of Sld7 in complex with Sld3 is presented. Sld7 comprises two structural domains.
    Title: The quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated DNA replication initiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated DNA replication initiation IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of DNA replication preinitiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome, centromeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum HDA PubMed 
located_in nuclear envelope HDA PubMed 
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Sld7p
NP_014703.1
  • Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria; ortholog of human MTBP, which is a DNA replication origin firing factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    440390..441163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183479.1 → NP_014703.1  TPA: Sld7p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014703.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2C3, O00023, Q08457
    UniProtKB/TrEMBL
    G2WMT8, N1NYA6
    Conserved Domains (2) summary
    pfam18596
    Location:181 → 255
    Sld7_C; Sld7 C-terminal domain
    pfam18636
    Location:3 → 125
    Sld7_N; Mitochondrial morphogenesis protein SLD7 N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08457.1

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