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OST2 dolichyl-diphosphooligosaccharide-protein glycotransferase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854270, updated on 9-Dec-2024

Summary

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Official Symbol
OST2
Official Full Name
dolichyl-diphosphooligosaccharide-protein glycotransferase
Primary source
SGD:S000005629
Locus tag
YOR103C
See related
AllianceGenome:SGD:S000005629; FungiDB:YOR103C; VEuPathDB:YOR103C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in protein N-linked glycosylation. Located in endoplasmic reticulum. Part of oligosaccharyltransferase complex. Orthologous to human DAD1 (defender against cell death 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See OST2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (516449..516841, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene carnitine:acyl carnitine antiporter Neighboring gene Ras family GTPase RAS1 Neighboring gene Pin2p Neighboring gene uncharacterized protein Neighboring gene SNAP receptor VAM3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast cell death caused by mutation of the OST2 gene encoding the epsilon-subunit of Saccharomyces cerevisiae oligosaccharyltransferase. Sugiura M, et al. Biosci Biotechnol Biochem, 2006 May. PMID 16717427
  2. The essential OST2 gene encodes the 16-kD subunit of the yeast oligosaccharyltransferase, a highly conserved protein expressed in diverse eukaryotic organisms. Silberstein S, et al. J Cell Biol, 1995 Oct. PMID 7593165, Free PMC Article
  3. Defects in N-glycosylation induce apoptosis in yeast. Hauptmann P, et al. Mol Microbiol, 2006 Feb. PMID 16420350
  4. A dual affinity tag on the 64-kDa Nlt1p subunit allows the rapid characterization of mutant yeast oligosaccharyl transferase complexes. Pathak R, et al. Arch Biochem Biophys, 1997 Feb 1. PMID 9015380
  5. The Saccharomyces cerevisiae oligosaccharyltransferase is a protein complex composed of Wbp1p, Swp1p, and four additional polypeptides. Kelleher DJ, et al. J Biol Chem, 1994 Apr 29. PMID 8175708

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Apoptosis-like cell death in ost2 mutants is caused by the secondary effect of overall reduced protein N-linked glycosylation.
    Title: Yeast cell death caused by mutation of the OST2 gene encoding the epsilon-subunit of Saccharomyces cerevisiae oligosaccharyltransferase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein N-linked glycosylation IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of oligosaccharyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of oligosaccharyltransferase complex IEA
Inferred from Electronic Annotation
more info
  
part_of oligosaccharyltransferase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
dolichyl-diphosphooligosaccharide-protein glycotransferase
NP_014746.2
  • Non-catalytic epsilon subunit of the oligosaccharyltransferase (OST) complex; the OST complex catalyzes asparagine-linked glycosylation of newly synthesized proteins in the ER; forms a pocket with Wbp1p involved in binding terminal glucose units of the donor glycan; located in the ER lumen

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    516449..516841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183522.1 → NP_014746.2  TPA: dolichyl-diphosphooligosaccharide-protein glycotransferase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014746.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2G3, P46964
    UniProtKB/TrEMBL
    A6ZNV2, B3LJE8, C7GMN2, G2WMX9, N1NVS4
    Conserved Domains (1) summary
    pfam02109
    Location:24 → 130
    DAD; DAD family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46964.3

Gene LinkOut

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