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TFC7 transcription factor TFIIIC subunit TFC7 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854277, updated on 9-Dec-2024

Summary

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Official Symbol
TFC7
Official Full Name
transcription factor TFIIIC subunit TFC7
Primary source
SGD:S000005636
Locus tag
YOR110W
See related
AllianceGenome:SGD:S000005636; FungiDB:YOR110W; VEuPathDB:YOR110W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables phosphatase activity. Contributes to DNA binding activity and RNA polymerase III general transcription initiation factor activity. Involved in 5S class rRNA transcription by RNA polymerase III. Part of transcription factor TFIIIC complex. Orthologous to human UBASH3A (ubiquitin associated and SH3 domain containing A) and UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TFC7 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (528941..530248)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene 2-isopropylmalate synthase LEU9 Neighboring gene phosphatidylinositol-3-/phosphoinositide 5-phosphatase INP53 Neighboring gene nucleotide diphosphatase Neighboring gene Cex1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Detection of modifications in the glucose metabolism induced by genetic mutations in Saccharomyces cerevisiae by 13C- and H-NMR spectroscopy. Herve M, et al. Eur J Biochem, 2000 Jun. PMID 10824121
  2. Structural and functional characterization of a phosphatase domain within yeast general transcription factor IIIC. Taylor NM, et al. J Biol Chem, 2013 May 24. PMID 23569204, Free PMC Article
  3. A truncation mutant of the 95-kilodalton subunit of transcription factor IIIC reveals asymmetry in Ty3 integration. Aye M, et al. Mol Cell Biol, 2001 Nov. PMID 11604518, Free PMC Article
  4. A suppressor of mutations in the class III transcription system encodes a component of yeast TFIIIB. Rüth J, et al. EMBO J, 1996 Apr 15. PMID 8617241, Free PMC Article
  5. Saccharomyces cerevisiae transcription factors IIIB and IIIC bend the DNA of a tRNA(Gln) gene. Léveillard T, et al. J Biol Chem, 1991 Mar 15. PMID 2002052

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
contributes_to DNA binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase III general transcription initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase III general transcription initiation factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
contributes_to RNA polymerase III type 1 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to RNA polymerase III type 2 promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 5S class rRNA transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase III IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIIC complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor TFIIIC subunit TFC7
NP_014753.1
  • RNA pol III transcription initiation factor complex (TFIIIC) subunit; part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; TFC7 has a paralog, YNL108C, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    528941..530248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183529.1 → NP_014753.1  TPA: transcription factor TFIIIC subunit TFC7 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014753.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2G9, Q07347, Q12415, Q6B220
    UniProtKB/TrEMBL
    B3LJF3, B5VS00, C7GMM6, C8ZI72, G2WMY6, N1NWY5
    Conserved Domains (2) summary
    COG0406
    Location:5 → 186
    PhoE; Broad specificity phosphatase PhoE [Carbohydrate transport and metabolism]
    pfam10419
    Location:289 → 368
    TFIIIC_sub6; TFIIIC subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q12415.1

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