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DCS2 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854344, updated on 4-Jan-2025

Summary

Official Symbol
DCS2
Official Full Name
5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
Primary source
SGD:S000005699
Locus tag
YOR173W
See related
AllianceGenome:SGD:S000005699; FungiDB:YOR173W; VEuPathDB:YOR173W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables enzyme inhibitor activity. Involved in cellular response to starvation and deadenylation-dependent decapping of nuclear-transcribed mRNA. Located in P-body. Orthologous to human DCPS (decapping enzyme, scavenger). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See DCS2 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (657264..658325)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene sphinganine kinase LCB4 Neighboring gene Yrm1p Neighboring gene Med4p Neighboring gene lysophospholipid acyltransferase

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA 7-methylguanosine cap binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in P-body IDA
Inferred from Direct Assay
more info
PubMed 
located_in P-body IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase
NP_014816.2
  • m(7)GpppX pyrophosphatase regulator; non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance; DCS2 has a paralog, DCS1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    657264..658325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183592.1NP_014816.2  TPA: 5'-(N(7)-methyl 5'-triphosphoguanosine)-(mRNA) diphosphatase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014816.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2M9, Q12123
    UniProtKB/TrEMBL
    C7GN54, N1NWQ1
    Conserved Domains (1) summary
    COG5075
    Location:3329
    COG5075; Uncharacterized conserved protein [Function unknown]