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HEM15 ferrochelatase HEM15 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854347, updated on 4-Jan-2025

Summary

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Official Symbol
HEM15
Official Full Name
ferrochelatase HEM15
Primary source
SGD:S000005702
Locus tag
YOR176W
See related
AllianceGenome:SGD:S000005702; FungiDB:YOR176W; VEuPathDB:YOR176W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ferrochelatase activity. Involved in heme biosynthetic process. Located in mitochondrial inner membrane. Used to study cancer. Human ortholog(s) of this gene implicated in cutaneous porphyria and erythropoietic protoporphyria. Orthologous to human FECH (ferrochelatase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See HEM15 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (662401..663582)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Med4p Neighboring gene lysophospholipid acyltransferase Neighboring gene tRNA-Val Neighboring gene Mpc54p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation and functional characterization of mutant ferrochelatases in Saccharomyces cerevisiae. Góra M, et al. Biochimie, 1996. PMID 8818224
  2. Examination of the activity of carboxyl-terminal chimeric constructs of human and yeast ferrochelatases. Medlock AE, et al. Biochemistry, 2000 Jun 27. PMID 10858295
  3. Yeast ferrochelatase: expression in a baculovirus system and purification of the expression protein. Eldridge MG, et al. Protein Sci, 1992 Feb. PMID 1304908, Free PMC Article
  4. The ferrochelatase from Saccharomyces cerevisiae. Sequence, disruption, and expression of its structural gene HEM15. Labbe-Bois R. J Biol Chem, 1990 May 5. PMID 2185242
  5. Purification and properties of ferrochelatase from the yeast Saccharomyces cerevisiae. Evidence for a precursor form of the protein. Camadro JM, et al. J Biol Chem, 1988 Aug 25. PMID 3042776

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ferrochelatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferrochelatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferrochelatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ferrochelatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heme biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heme biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ferrochelatase HEM15
NP_014819.3
  • Ferrochelatase; a mitochondrial inner membrane protein, catalyzes insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; human homolog FECH can complement yeast mutant and allow growth of haploid null after sporulation of a heterozygous diploid

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    662401..663582
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183595.3 → NP_014819.3  TPA: ferrochelatase HEM15 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014819.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2N2, P16622
    UniProtKB/TrEMBL
    A7A2C1, B3LJK6, C7GN51, C8ZGT7, G2WN49, N1NYK0
    Conserved Domains (1) summary
    TIGR00109
    Location:34 → 358
    hemH; ferrochelatase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P16622.1

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