GAC1 protein phosphatase regulator GAC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: GAC1
Official Full Name: protein phosphatase regulator GAC1
Primary source: SGD:S000005704
Locus tag: YOR178C
See related: AllianceGenome:SGD:S000005704; FungiDB:YOR178C; VEuPathDB:YOR178C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables heat shock protein binding activity and protein phosphatase regulator activity. Involved in several processes, including glycogen metabolic process; mitotic spindle assembly checkpoint signaling; and response to heat. Part of protein phosphatase type 1 complex. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to several human genes including PPP1R3A (protein phosphatase 1 regulatory subunit 3A); PPP1R3B (protein phosphatase 1 regulatory subunit 3B); and PPP1R3C (protein phosphatase 1 regulatory subunit 3C). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables glycogen binding	IBA Inferred from Biological aspect of Ancestor more info
enables heat shock protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein phosphatase 1 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein phosphatase regulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in glycogen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in glycogen metabolic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in meiotic cell cycle	IPI Inferred from Physical Interaction more info	PubMed
involved_in mitotic spindle assembly checkpoint signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glycogen biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of protein phosphatase type 1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein phosphatase type 1 complex	IDA Inferred from Direct Assay more info	PubMed

NP_014821.3

Regulatory subunit for Glc7p type-1 protein phosphatase (PP1); tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock; GAC1 has a paralog, PIG1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain