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TOA1 transcription initiation factor IIA large subunit [ Saccharomyces cerevisiae S288C ]

Gene ID: 854369, updated on 9-Dec-2024

Summary

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Official Symbol
TOA1
Official Full Name
transcription initiation factor IIA large subunit
Primary source
SGD:S000005720
Locus tag
YOR194C
See related
AllianceGenome:SGD:S000005720; FungiDB:YOR194C; VEuPathDB:YOR194C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables transcription coregulator activity. Contributes to TBP-class protein binding activity. Involved in RNA polymerase II preinitiation complex assembly. Part of transcription factor TFIIA complex. Orthologous to several human genes including GTF2A1 (general transcription factor IIA subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TOA1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (711683..712543, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tRNA-Met Neighboring gene Pex27p Neighboring gene Slk19p Neighboring gene putative lipoate synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional activation in yeast cells lacking transcription factor IIA. Chou S, et al. Genetics, 1999 Dec. PMID 10581267, Free PMC Article
  2. Improved method for soluble expression and rapid purification of yeast TFIIA. Adachi N, et al. Protein Expr Purif, 2017 May. PMID 28259734
  3. High-resolution mapping of nucleoprotein complexes by site-specific protein-DNA photocrosslinking: organization of the human TBP-TFIIA-TFIIB-DNA quaternary complex. Lagrange T, et al. Proc Natl Acad Sci U S A, 1996 Oct 1. PMID 8855228, Free PMC Article
  4. Five intermediate complexes in transcription initiation by RNA polymerase II. Buratowski S, et al. Cell, 1989 Feb 24. PMID 2917366
  5. TFIIA has activator-dependent and core promoter functions in vivo. Stargell LA, et al. J Biol Chem, 2000 Apr 28. PMID 10777519

See all (87) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
contributes_to TBP-class protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to TBP-class protein binding IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription coregulator activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in RNA polymerase II preinitiation complex assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transcription initiation at RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIIA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIIA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIIA complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription initiation factor IIA large subunit
NP_014837.1
  • TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; required, along with Toa2p, for ribosomal protein gene transcription in vivo; homologous to largest and second largest subunits of human and Drosophila TFIIA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    711683..712543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183613.1 → NP_014837.1  TPA: transcription initiation factor IIA large subunit [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014837.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2Q3, E9P936, P32773
    UniProtKB/TrEMBL
    A6ZP40, B3LJM4, B5VS79, C7GWI5, C8ZGV3, G2WN69, N1P3D1
    Conserved Domains (1) summary
    cl21683
    Location:1 → 286
    TFIIA_alpha_beta_like; Precursor of TFIIA alpha and beta subunits and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P32773.1

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