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BFR1 Bfr1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854373, updated on 4-Jan-2025

Summary

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Official Symbol
BFR1
Official Full Name
Bfr1p
Primary source
SGD:S000005724
Locus tag
YOR198C
See related
AllianceGenome:SGD:S000005724; FungiDB:YOR198C; VEuPathDB:YOR198C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in several processes, including cellular response to glucose starvation; protein O-linked mannosylation; and protein insertion into ER membrane. Located in endoplasmic reticulum and nuclear outer membrane-endoplasmic reticulum membrane network. Part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See BFR1 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (718653..720065, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene putative lipoate synthase Neighboring gene Ca(2+)-dependent cysteine protease MCA1 Neighboring gene Mrm1p Neighboring gene imidazoleglycerol-phosphate dehydratase HIS3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast mutants that produce a novel type of ascus containing asci instead of spores. Xue Z, et al. Genetics, 1996 Nov. PMID 8913743, Free PMC Article
  2. Both KH and non-KH domain sequences are required for polyribosome association of Scp160p in yeast. Li AM, et al. Nucleic Acids Res, 2004. PMID 15356294, Free PMC Article
  3. Local translation of yeast ERG4 mRNA at the endoplasmic reticulum requires the brefeldin A resistance protein Bfr1. Manchalu S, et al. RNA, 2019 Dec. PMID 31455610, Free PMC Article
  4. BFR1, a multicopy suppressor of brefeldin A-induced lethality, is implicated in secretion and nuclear segregation in Saccharomyces cerevisiae. Jackson CL, et al. Genetics, 1994 Jun. PMID 8070655, Free PMC Article
  5. Scp160p, a multiple KH-domain protein, is a component of mRNP complexes in yeast. Lang BD, et al. Nucleic Acids Res, 2000 Apr 1. PMID 10710424, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results identify Bfr1 affecting O-mannosylation through changes in Pmt1 and Pmt2 protein abundance but has no effect on PMT1 and PMT2 transcript levels, mRNA localization to the ER membrane or protein stability. Ribosome profiling reveals that Bfr1 is a crucial factor for Pmt1 and Pmt2 translation thereby affecting unfolded protein O-mannosylation.
    Title: Translational Regulation of Pmt1 and Pmt2 by Bfr1 Affects Unfolded Protein O-Mannosylation.
  2. Bfr1p is a latephaselocalizing Pbody protein that is important for the delayed entry of certain mRNAS to Pbodies.
    Title: mRNA localization to P-bodies in yeast is bi-phasic with many mRNAs captured in a late Bfr1p-dependent wave.
  3. Data propose that Bfr1p regulates the secretory pathway protein abundance levels in the presence of elevated ER stress and acts as a checkpoint in monitoring the levels of ER stress and the function of kinetochores before regulating its own levels.
    Title: Kinetochore genes are required to fully activate secretory pathway expansion in S. cerevisiae under induced ER stress.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding HDA PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular mRNA localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular mRNA localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked mannosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein insertion into ER membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in nuclear outer membrane-endoplasmic reticulum membrane network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear outer membrane-endoplasmic reticulum membrane network IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Bfr1p
NP_014841.1
  • Component of mRNP complexes associated with polyribosomes; involved in localization of mRNAs to P bodies; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    718653..720065 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183617.1 → NP_014841.1  TPA: Bfr1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014841.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2Q7, P38934
    UniProtKB/TrEMBL
    A6ZP44, B5VS83, C7GWI1, C8ZGV7, G2WN73, N1P3E6
    Conserved Domains (1) summary
    COG1196
    Location:3 → 277
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38934.1

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