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NAT5 peptide alpha-N-acetyltransferase subunit NAT5 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854427, updated on 4-Jan-2025

Summary

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Official Symbol
NAT5
Official Full Name
peptide alpha-N-acetyltransferase subunit NAT5
Primary source
SGD:S000005779
Locus tag
YOR253W
See related
AllianceGenome:SGD:S000005779; FungiDB:YOR253W; VEuPathDB:YOR253W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ARD2; NAA50; ROG2
Summary
Enables peptide alpha-N-acetyltransferase activity. Involved in N-terminal protein amino acid acetylation. Part of NatA complex. Orthologous to human NAA50 (N-alpha-acetyltransferase 50, NatE catalytic subunit). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See NAT5 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (804377..804907)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene thiosulfate sulfurtransferase Neighboring gene Tma16p Neighboring gene protein-transporting protein SEC63 Neighboring gene Osw1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. ARD1 and NAT1 proteins form a complex that has N-terminal acetyltransferase activity. Park EC, et al. EMBO J, 1992 Jun. PMID 1600941, Free PMC Article
  2. Identification and characterization of genes and mutants for an N-terminal acetyltransferase from yeast. Mullen JR, et al. EMBO J, 1989 Jul. PMID 2551674, Free PMC Article
  3. N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases. Van Damme P, et al. Proteomics, 2015 Jul. PMID 25886145
  4. Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation. Knorr AG, et al. Nat Struct Mol Biol, 2019 Jan. PMID 30559462
  5. The yeast N(alpha)-acetyltransferase NatA is quantitatively anchored to the ribosome and interacts with nascent polypeptides. Gautschi M, et al. Mol Cell Biol, 2003 Oct. PMID 14517307, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The study quantitatively compared the Nt-acetylomes of wild-type yeast S. cerevisiae expressing the endogenous yeast Naa50 (yNaa50), the congenic strain lacking yNaa50, and an otherwise identical strain expressing human Naa50 (hNaa50).
    Title: N-terminal acetylome analysis reveals the specificity of Naa50 (Nat5) and suggests a kinetic competition between N-terminal acetyltransferases and methionine aminopeptidases.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity, transferring groups other than amino-acyl groups IEA
Inferred from Electronic Annotation
more info
  
enables peptide alpha-N-acetyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables peptide-methionine-alpha-N-acetyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-terminal protein amino acid acetylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of NatA complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of NatA complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
peptide alpha-N-acetyltransferase subunit NAT5
NP_014896.3
  • Subunit of protein N-terminal acetyltransferase NatA; NatA is comprised of Nat1p, Ard1p, and Nat5p; N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    804377..804907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183672.3 → NP_014896.3  TPA: peptide alpha-N-acetyltransferase subunit NAT5 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014896.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W2V4, Q08689
    UniProtKB/TrEMBL
    A6ZP91, B3LJS1, B5VSD4, C7GWD6, C8ZH05, G2WNC1, N1NXA3
    Conserved Domains (1) summary
    pfam00583
    Location:63 → 147
    Acetyltransf_1; Acetyltransferase (GNAT) family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08689.1

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