YTM1 Ytm1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: YTM1
Official Full Name: Ytm1p
Primary source: SGD:S000005798
Locus tag: YOR272W
See related: AllianceGenome:SGD:S000005798; FungiDB:YOR272W; VEuPathDB:YOR272W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: CST14
Summary: Predicted to enable ribonucleoprotein complex binding activity. Involved in chromosome organization; protein-RNA complex remodeling; and ribosomal large subunit biogenesis. Located in nucleolus. Part of PeBoW complex and preribosome, large subunit precursor. Orthologous to human WDR12 (WD repeat domain 12). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See YTM1 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (832813..834195)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ytm1, Erb1, and Nop7 are required for assembly of the Nop7-subcomplex in yeast preribosomes
Title: Interactions among Ytm1, Erb1, and Nop7 required for assembly of the Nop7-subcomplex in yeast preribosomes.
Nop7 and Erb1 assemble into preribosomes prior to Ytm1
Title: Ytm1, Nop7, and Erb1 form a complex necessary for maturation of yeast 66S preribosomes.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info
enables ribonucleoprotein complex binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA Inferred from Electronic Annotation more info
involved_in protein-RNA complex remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	IEA Inferred from Electronic Annotation more info
involved_in ribosomal large subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of PeBoW complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PeBoW complex	IDA Inferred from Direct Assay more info	PubMed
part_of PeBoW complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	HDA more info	PubMed
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info
part_of preribosome, large subunit precursor	IDA Inferred from Direct Assay more info	PubMed
part_of preribosome, large subunit precursor	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ytm1p

NP_014915.3

Ribosomal assembly factor and 66S pre-ribosomal particle constituent; subunit of the Nop7-subcomplex (PeBoW complex), required for an early nucleolar step in pre-60S ribosomal particle maturation; interaction of its ubiquitin-like (UBL) domain with the MIDAS domain in the Rea1p tail triggers release of the subcomplex and possibly other biogenesis factors via cycles of ATP hydrolysis; involved in the processing of 27S pre-rRNA; contains an N-terminal UBL domain and seven C-terminal WD repeats

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

832813..834195

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183691.3 → NP_014915.3 TPA: Ytm1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014915.3

Status: REVIEWED

UniProtKB/Swiss-Prot

A6ZPA9, D6W2X2, Q12024

UniProtKB/TrEMBL

G2WNE0, N1P3M1

Conserved Domains (3) summary

cd00200
Location:103 → 451

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:106 → 142

7WD40; WD40 repeat [structural motif]

pfam08154
Location:8 → 72

NLE; NLE (NUC135) domain