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MSC6 Msc6p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854536, updated on 9-Dec-2024

Summary

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Official Symbol
MSC6
Official Full Name
Msc6p
Primary source
SGD:S000005881
Locus tag
YOR354C
See related
AllianceGenome:SGD:S000005881; FungiDB:YOR354C; VEuPathDB:YOR354C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables mRNA binding activity. Involved in mitochondrial translational initiation and reciprocal meiotic recombination. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See MSC6 in Genome Data Viewer
Location:
chromosome: XV
Exon count:
1
Sequence:
Chromosome: XV; NC_001147.6 (1001147..1003225, complement)

Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene TFIIH complex subunit TFB6 Neighboring gene Sog2p Neighboring gene Gds1p Neighboring gene putative electron-transferring-flavoprotein dehydrogenase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Msc6p is required for mitochondrial translation initiation in the absence of formylated Met-tRNA(fMet). Franco LVR, et al. FEBS J, 2019 Apr. PMID 30767393
  2. Partial suppression of the respiratory defect of qrs1/her2 glutamyl-tRNA amidotransferase mutants by overexpression of the mitochondrial pentatricopeptide Msc6p. Moda BS, et al. Curr Genet, 2016 Aug. PMID 26780366
  3. Genetic control of recombination partner preference in yeast meiosis. Isolation and characterization of mutants elevated for meiotic unequal sister-chromatid recombination. Thompson DA, et al. Genetics, 1999 Oct. PMID 10511544, Free PMC Article
  4. Gene overexpression screen for chromosome instability in yeast primarily identifies cell cycle progression genes. Tutaj H, et al. Curr Genet, 2019 Apr. PMID 30244280, Free PMC Article
  5. Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Lin YY, et al. Cell, 2009 Mar 20. PMID 19303850, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables mRNA binding HDA PubMed 
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial translational initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reciprocal meiotic recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Msc6p
NP_014999.1
  • Multicopy suppressor of HER2 involved in mitochondrial translation; mutant is defective in directing meiotic recombination events to homologous chromatids

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001147.6 Reference assembly

    Range
    1001147..1003225 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001183774.1 → NP_014999.1  TPA: Msc6p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_014999.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W349, Q08818
    UniProtKB/TrEMBL
    B3LK11, N1NZ02
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08818.1

Gene LinkOut

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