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CSM2 Csm2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854674, updated on 9-Dec-2024

Summary

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Official Symbol
CSM2
Official Full Name
Csm2p
Primary source
SGD:S000001394
Locus tag
YIL132C
See related
AllianceGenome:SGD:S000001394; FungiDB:YIL132C; VEuPathDB:YIL132C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in DNA recombinase assembly; maintenance of rDNA; and meiotic chromosome segregation. Located in site of double-strand break. Part of Shu complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CSM2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (99860..100501, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene flavin adenine dinucleotide transporter FLX1 Neighboring gene ribosomal 60S subunit protein L16A Neighboring gene forkhead family transcription factor FKH1 Neighboring gene Asg1p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions. Bonilla B, et al. Elife, 2021 Nov 1. PMID 34723799, Free PMC Article
  2. Genome Profiling for Aflatoxin B(1) Resistance in Saccharomyces cerevisiae Reveals a Role for the CSM2/SHU Complex in Tolerance of Aflatoxin B(1)-Associated DNA Damage. St John N, et al. G3 (Bethesda), 2020 Nov 5. PMID 32994210, Free PMC Article
  3. Structural analysis of Shu proteins reveals a DNA binding role essential for resisting damage. Tao Y, et al. J Biol Chem, 2012 Jun 8. PMID 22465956, Free PMC Article
  4. Structural and SAXS analysis of the budding yeast SHU-complex proteins. She Z, et al. FEBS Lett, 2012 Jul 30. PMID 22749910
  5. The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination. Godin S, et al. Nucleic Acids Res, 2013 Apr. PMID 23460207, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study provides evidence that DNA-binding components of the budding yeast Shu complex, Csm2-Psy3, bind double-flap DNA substrates containing an abasic site analog, and increase chromatin association when abasic sites accumulate. Importantly, Csm2-Psy3 blocks AP endonuclease cleavage at a double-flap DNA substrate, thus preventing in vitro double-strand break formation.
    Title: The Rad51 paralogs facilitate a novel DNA strand specific damage tolerance pathway.
  2. Data indicate that Csm2, Psy3, Shu1 and Shu2 interact with each other in sequence to form a V-shape overall structure in Shu complex.
    Title: Structural basis for the functional role of the Shu complex in homologous recombination.
  3. The data suggest a model in which Csm2-Psy3 recruit the Shu complex to homologous recombination substrates, where it interacts with Rad51 through Rad55-Rad57 to stimulate Rad51 filament assembly and stability, promoting error-free repair.
    Title: The Shu complex interacts with Rad51 through the Rad51 paralogues Rad55-Rad57 to mediate error-free recombination.
  4. analysis of the crystal structure of the Psy3-Csm2 sub-complex
    Title: Structural and SAXS analysis of the budding yeast SHU-complex proteins.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA recombinase assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of rDNA IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic chromosome segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in recombinational repair IEA
Inferred from Electronic Annotation
more info
  
involved_in recombinational repair IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in recombinational repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of Shu complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Shu complex IEA
Inferred from Electronic Annotation
more info
  
part_of Shu complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in site of double-strand break IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Csm2p
NP_012134.1
  • Subunit of the Shu complex (aka PCSS complex); Shu complex also includes Psy3, Shu1, Shu2, and promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p anti-recombinase function; promotes formation of Rad51p filaments; Psy3p and Csm2p contain similar DNA-binding regions which work together to form a single DNA binding site; required for accurate chromosome segregation during meiosis

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    99860..100501 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179480.1 → NP_012134.1  TPA: Csm2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012134.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVF5, P40465, Q45U15
    UniProtKB/TrEMBL
    C7GUP9
    Conserved Domains (1) summary
    cd19478
    Location:7 → 212
    Csm2; Shu complex subunit Csm2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40465.1

Gene LinkOut

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