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ICE2 Ice2p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854718, updated on 9-Dec-2024

Summary

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Official Symbol
ICE2
Official Full Name
Ice2p
Primary source
SGD:S000001352
Locus tag
YIL090W
See related
AllianceGenome:SGD:S000001352; FungiDB:YIL090W; VEuPathDB:YIL090W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables protein serine/threonine phosphatase inhibitor activity. Involved in several processes, including endoplasmic reticulum organization; protein localization to membrane; and septin ring assembly. Located in endoplasmic reticulum membrane and perinuclear endoplasmic reticulum. Is active in cortical endoplasmic reticulum. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ICE2 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (193595..195070)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene rRNA-binding ribosome biosynthesis protein UTP25 Neighboring gene uncharacterized protein Neighboring gene tRNA-Glu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide functional profiling identifies genes and processes important for zinc-limited growth of Saccharomyces cerevisiae. North M, et al. PLoS Genet, 2012. PMID 22685415, Free PMC Article
  2. Over-expression of ICE2 stabilizes cytochrome P450 reductase in Saccharomyces cerevisiae and Pichia pastoris. Emmerstorfer A, et al. Biotechnol J, 2015 Apr. PMID 25641738
  3. Ice2p is important for the distribution and structure of the cortical ER network in Saccharomyces cerevisiae. Estrada de Martin P, et al. J Cell Sci, 2005 Jan 1. PMID 15585575
  4. Fungal Ice2p is in the same superfamily as SERINCs, restriction factors for HIV and other viruses. Alli-Balogun GO, et al. Proteins, 2021 Oct. PMID 33982326
  5. An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER. Markgraf DF, et al. Cell Rep, 2014 Jan 16. PMID 24373967, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex.
    Title: Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex.
  2. Ice2p interacts with lipid droplets and promotes triacylglycerol utilization for phospholipid synthesis.
    Title: An ER protein functionally couples neutral lipid metabolism on lipid droplets to membrane lipid synthesis in the ER.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein serine/threonine phosphatase inhibitor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein serine/threonine phosphatase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoplasmic reticulum inheritance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum inheritance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum membrane biogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in endoplasmic reticulum membrane biogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular zinc ion homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-translational protein targeting to membrane, translocation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to nuclear inner membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in septin ring assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in septin ring assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cortical endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cortical endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Ice2p
NP_012176.1
  • Integral ER membrane protein with type-III transmembrane domains; promotes ER membrane expansion by inhibiting the Nem1-Spo7 phosphatase complex, resulting in reduced dephosphorylation and activation of Pah1p; maintains homeostasis during ER stress; required for post-translational SRP-independent protein translocation into the ER; necessary for efficient targeting of the Trm1p to the inner nuclear membrane; mutations cause defects in cortical ER morphology; member of the SERINC superfamily

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    193595..195070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179438.1 → NP_012176.1  TPA: Ice2p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012176.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVJ7, P40499, Q6B2T7
    UniProtKB/TrEMBL
    A6ZVI7, B3LTT7, B5VKL7, C7GKL7, C8ZAF9, N1P9B8
    Conserved Domains (1) summary
    pfam08426
    Location:14 → 488
    ICE2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40499.1

Gene LinkOut

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