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gag-pol fusion protein [ Saccharomyces cerevisiae S288C ]

Gene ID: 854728, updated on 9-Dec-2024

Summary

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Official Full Name
gag-pol fusion protein
Primary source
SGD:S000003537
Locus tag
YIL082W-A
See related
AllianceGenome:SGD:S000003537; FungiDB:YIL082W-A; VEuPathDB:YIL082W-A
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable several functions, including DNA polymerase activity; RNA nuclease activity; and peptidase activity. Predicted to be involved in retrotransposition. Located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (205635..210132)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Sds3p Neighboring gene phosphopantothenate--cysteine ligase CAB2 Neighboring gene tRNA-Ile Neighboring gene TRAMP complex RNA-binding subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Integrase mediates nuclear localization of Ty3. Lin SS, et al. Mol Cell Biol, 2001 Nov. PMID 11604517, Free PMC Article
  2. Mutating conserved residues in the ribonuclease H domain of Ty3 reverse transcriptase affects specialized cleavage events. Lener D, et al. J Biol Chem, 2002 Jul 19. PMID 11994277
  3. Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase. Bibillo A, et al. Nucleic Acids Res, 2005. PMID 15647500, Free PMC Article
  4. Ty3 nucleocapsid controls localization of particle assembly. Larsen LS, et al. J Virol, 2008 Mar. PMID 18094177, Free PMC Article
  5. TY3 GAG3 protein forms ordered particles in Escherichia coli. Larsen LS, et al. Virology, 2008 Jan 20. PMID 17964628, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA nuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA-DNA hybrid ribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA-directed DNA polymerase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables aspartic-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables telomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA integration IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in RNA-templated DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in retrotransposition ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in viral translational frameshifting IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in retrotransposon nucleocapsid ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
gag-pol fusion protein
NP_012184.1
  • Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    205635..210132
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001181434.4 → NP_012184.1  TPA: gag-pol fusion protein [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012184.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVK4, Q04717, Q04722, Q05350, Q7LHG5
    Conserved Domains (6) summary
    cd01647
    Location:649 → 823
    RT_LTR; RT_LTR: Reverse transcriptases (RTs) from retrotransposons and retroviruses which have long terminal repeats (LTRs) in their DNA copies but not in their RNA template. RT catalyzes DNA replication from an RNA template, and is responsible for the ...
    pfam03732
    Location:70 → 157
    Retrotrans_gag; Retrotransposon gag protein
    cd09274
    Location:915 → 1034
    RNase_HI_RT_Ty3; Ty3/Gypsy family of RNase HI in long-term repeat retroelements
    pfam00078
    Location:665 → 823
    RVT_1; Reverse transcriptase (RNA-dependent DNA polymerase)
    pfam00665
    Location:1198 → 1306
    rve; Integrase core domain
    cl11403
    Location:286 → 462
    pepsin_retropepsin_like; Cellular and retroviral pepsin-like aspartate proteases
Nucleotide Protein
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