THS1 threonine--tRNA ligase THS1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: THS1
Official Full Name: threonine--tRNA ligase THS1
Primary source: SGD:S000001340
Locus tag: YIL078W
See related: AllianceGenome:SGD:S000001340; FungiDB:YIL078W; VEuPathDB:YIL078W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables sequence-specific mRNA binding activity and threonine-tRNA ligase activity. Involved in threonyl-tRNA aminoacylation. Located in cytoplasm. Used to study amino acid metabolic disorder and nonphotosensitive trichothiodystrophy. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 21 and nonphotosensitive trichothiodystrophy 7. Orthologous to several human genes including TARS3 (threonyl-tRNA synthetase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See THS1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (212499..214703)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of critical residues in ThrS based on lethal mutations in yeast
Title: Identification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables aminoacyl-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity, acting on a tRNA	IEA Inferred from Electronic Annotation more info
enables sequence-specific mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables threonine-tRNA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine-tRNA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables threonine-tRNA ligase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in tRNA aminoacylation for protein translation	IEA Inferred from Electronic Annotation more info
involved_in threonyl-tRNA aminoacylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in threonyl-tRNA aminoacylation	IDA Inferred from Direct Assay more info	PubMed
involved_in threonyl-tRNA aminoacylation	IEA Inferred from Electronic Annotation more info
involved_in translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: threonine--tRNA ligase THS1

NP_116578.3

EC 6.1.1.3

Threonyl-tRNA synthetase involved in tRNA aminoacylation; mRNA binding protein that preferentially binds to the mRNA of RNAPI subunits and DNA binding proteins; binds to an anticodon stem loop-like structure in RPC10 and impacts its translation; cytoplasmic protein; human homolog TARS can complement a yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

212499..214703

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179428.3 → NP_116578.3 TPA: threonine--tRNA ligase THS1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_116578.3

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVK6, P04801

UniProtKB/TrEMBL

A6ZVJ5

Conserved Domains (1) summary

PLN02908
Location:46 → 728

PLN02908; threonyl-tRNA synthetase