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SEC28 coatomer subunit epsilon [ Saccharomyces cerevisiae S288C ]

Gene ID: 854734, updated on 9-Dec-2024

Summary

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Official Symbol
SEC28
Official Full Name
coatomer subunit epsilon
Primary source
SGD:S000001338
Locus tag
YIL076W
See related
AllianceGenome:SGD:S000001338; FungiDB:YIL076W; VEuPathDB:YIL076W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
ANU2
Summary
Enables promoter-specific chromatin binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; late endosome to vacuole transport via multivesicular body sorting pathway; and vesicle coating. Part of COPI vesicle coat. Orthologous to human COPE (COPI coat complex subunit epsilon). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See SEC28 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (216658..217548)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene threonine--tRNA ligase THS1 Neighboring gene Rci37p Neighboring gene proteasome regulatory particle base subunit RPN2 Neighboring gene phosphoglycerate dehydrogenase SER33

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Comprehensive profiling of proteome changes upon sequential deletion of deubiquitylating enzymes. Poulsen JW, et al. J Proteomics, 2012 Jul 16. PMID 22634085
  2. Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP. Kimata Y, et al. J Biol Chem, 2000 Apr 7. PMID 10744762
  3. epsilon-COP is a structural component of coatomer that functions to stabilize alpha-COP. Duden R, et al. EMBO J, 1998 Feb 16. PMID 9463377, Free PMC Article
  4. Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat. Hsia KC, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534429, Free PMC Article
  5. The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation. Brown CR, et al. J Biol Chem, 2008 Sep 19. PMID 18660504, Free PMC Article

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat
    Title: Crystal structure of alpha-COP in complex with epsilon-COP provides insight into the architecture of the COPI vesicular coat.
  2. Vid24p and Sec28p are present at actin patches during glucose starvation.
    Title: The vacuole import and degradation pathway utilizes early steps of endocytosis and actin polymerization to deliver cargo proteins to the vacuole for degradation.
  3. Sec28p resides in Vid vesicles, and these vesicles converge with the endocytic pathway
    Title: The vacuolar import and degradation pathway merges with the endocytic pathway to deliver fructose-1,6-bisphosphatase to the vacuole for degradation.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in late endosome to vacuole transport via multivesicular body sorting pathway IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
involved_in vesicle coating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of COPI vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COPI vesicle coat IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COPI vesicle coat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in COPI-coated vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
coatomer subunit epsilon
NP_012189.2
  • Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    216658..217548
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179426.1 → NP_012189.2  TPA: coatomer subunit epsilon [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012189.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVK8, P40509
    UniProtKB/TrEMBL
    A6ZVJ7, B3LTS7, C7GKK7, C8ZAG9, G2WG72, N1P2J2
    Conserved Domains (1) summary
    pfam04733
    Location:4 → 293
    Coatomer_E; Coatomer epsilon subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40509.2

Gene LinkOut

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