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PCI8 Pci8p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854739, updated on 9-Dec-2024

Summary

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Official Symbol
PCI8
Official Full Name
Pci8p
Primary source
SGD:S000001333
Locus tag
YIL071C
See related
AllianceGenome:SGD:S000001333; FungiDB:YIL071C; VEuPathDB:YIL071C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CSN11; YIH1; YIL071W
Summary
Involved in protein deneddylation. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PCI8 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (228660..229994, complement)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene Spo22p Neighboring gene Hop1p Neighboring gene Mam33p Neighboring gene ribosomal 40S subunit protein S24B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Saccharomyces cerevisiae protein Pci8p and human protein eIF3e/Int-6 interact with the eIF3 core complex by binding to cognate eIF3b subunits. Shalev A, et al. J Biol Chem, 2001 Sep 14. PMID 11457827
  2. The COP9 signalosome is involved in the regulation of lipid metabolism and of transition metals uptake in Saccharomyces cerevisiae. Licursi V, et al. FEBS J, 2014 Jan. PMID 24164706
  3. Conservation of the COP9/signalosome in budding yeast. Wee S, et al. BMC Genet, 2002 Aug 20. PMID 12186635, Free PMC Article
  4. COP9 signalosome components play a role in the mating pheromone response of S. cerevisiae. Maytal-Kivity V, et al. EMBO Rep, 2002 Dec. PMID 12446563, Free PMC Article
  5. The COP9 signalosome-like complex in S. cerevisiae and links to other PCI complexes. Maytal-Kivity V, et al. Int J Biochem Cell Biol, 2003 May. PMID 12672462

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein deneddylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of COP9 signalosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pci8p
NP_085069.3
  • Possible shared subunit of Cop9 signalosome (CSN) and eIF3; binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    228660..229994 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179421.3 → NP_085069.3  TPA: Pci8p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_085069.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVL3, P40512
    UniProtKB/TrEMBL
    A6ZVK2, B3LTS3, C7GKK2, C8ZAH5, G2WG77, N1P4H7
    Conserved Domains (1) summary
    smart00088
    Location:296 → 387
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40512.1

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