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APQ12 Apq12p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854771, updated on 4-Jan-2025

Summary

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Official Symbol
APQ12
Official Full Name
Apq12p
Primary source
SGD:S000001302
Locus tag
YIL040W
See related
AllianceGenome:SGD:S000001302; FungiDB:YIL040W; VEuPathDB:YIL040W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in lipid homeostasis and nuclear envelope organization. Located in endoplasmic reticulum; membrane; and nuclear envelope. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See APQ12 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (277723..278139)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene protein kinase PKP1 Neighboring gene Gvp36p Neighboring gene Ted1p Neighboring gene CCR4-NOT core subunit NOT3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The yeast Apq12 protein affects nucleocytoplasmic mRNA transport. Baker KE, et al. RNA, 2004 Sep. PMID 15273328, Free PMC Article
  2. A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis. Zhang W, et al. Open Biol, 2021 Nov. PMID 34814743, Free PMC Article
  3. Genome-wide mRNA surveillance is coupled to mRNA export. Hieronymus H, et al. Genes Dev, 2004 Nov 1. PMID 15489286, Free PMC Article
  4. Direct binding of ESCRT protein Chm7 to phosphatidic acid-rich membranes at nuclear envelope herniations. Thaller DJ, et al. J Cell Biol, 2021 Mar 1. PMID 33464310, Free PMC Article
  5. Ssd1 is required for thermotolerance and Hsp104-mediated protein disaggregation in Saccharomyces cerevisiae. Mir SS, et al. Mol Cell Biol, 2009 Jan. PMID 18936161, Free PMC Article

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A short perinuclear amphipathic alpha-helix in Apq12 promotes nuclear pore complex biogenesis.
    Title: A short perinuclear amphipathic α-helix in Apq12 promotes nuclear pore complex biogenesis.
  2. Results report that Apq12 is required for efficient nuclear pore complex biogenesis in Saccharomyces cerevisiae.
    Title: The yeast integral membrane protein Apq12 potentially links membrane dynamics to assembly of nuclear pore complexes.
  3. Apq12 is found to interact with the kinetochore, revealing a novel relationship between nucleocytoplasmic transport and chromosome stability.
    Title: Genome-wide synthetic lethal screens identify an interaction between the nuclear envelope protein, Apq12p, and the kinetochore in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in lipid homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nuclear envelope organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Apq12p
NP_012224.1
  • Nuclear envelope/ER integral membrane protein; interacts and functions with Brr6p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA export from the nucleus and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    277723..278139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179390.1 → NP_012224.1  TPA: Apq12p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012224.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVP2, P40532
    UniProtKB/TrEMBL
    A6ZVM9, B3LTP6, C7GVW8, C8ZAK6, G2WGA6, N1P952
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40532.1

Gene LinkOut

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