IRR1 Irr1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: IRR1
Official Full Name: Irr1p
Primary source: SGD:S000001288
Locus tag: YIL026C
See related: AllianceGenome:SGD:S000001288; FungiDB:YIL026C; VEuPathDB:YIL026C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SCC3
Summary: Enables chromatin binding activity. Involved in mitotic sister chromatid cohesion. Located in cytosol and nucleus. Part of mitotic cohesin complex. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 47; primary ovarian insufficiency 8; and spermatogenic failure 61. Orthologous to human STAG1 (STAG1 cohesin complex component) and STAG3 (STAG3 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See IRR1 in Genome Data Viewer

Location:: chromosome: IX

Exon count:: 1

Sequence:: Chromosome: IX; NC_001141.2 (304477..307929, complement)

Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chromosome loading of cohesin depends on conserved residues in Scc3.
Title: Chromosome loading of cohesin depends on conserved residues in Scc3.
We demonstrate that this conserved domain is required for DNA binding by Scc3-Scc1 in vitro, as well as for the enrichment of cohesin on chromosomes and for cell viability. These findings suggest that the Scc3-Scc1 DNA-binding interface plays a central role in the recruitment of cohesin complexes to chromosomes and therefore for cohesin to faithfully execute its functions during cell division.
Title: Structural basis for Scc3-dependent cohesin recruitment to chromatin.
We show that residues Y371 and K372 within the SCD are critical for viability and chromosome condensation but dispensable for cohesion. However, scc3 Y371A and scc3 K372A bind normally to Mcd1
Title: A conserved domain in the scc3 subunit of cohesin mediates the interaction with both mcd1 and the cohesin loader complex.
Scc3 C-terminal domain binds Scc1 and promotes de-acetylation of Smc3 upon Scc1 cleavage.
Title: Structure and function of cohesin's Scc3/SA regulatory subunit.
expression of 33 genes is affected by the presence of the mutated Irr1-1p and identify those genes. This supports the suggested role of Irr1p in the regulation of transcription. Irr1p may interact with elements of transcriptional coactivator Mediator
Title: Cohesin Irr1/Scc3 is likely to influence transcription in Saccharomyces cerevisiae via interaction with Mediator complex.
The expression of MCD1 was not subject to Scc3 regulation in vegetative cells. Scc3 and Smc1 are both required for the production of the meiosis-specific subunit Rec8.
Title: Cohesin plays a dual role in gene regulation and sister-chromatid cohesion during meiosis in Saccharomyces cerevisiae.
The F658G substitutionin Irr1 was found to induce marked changes in the general shape of the predicted protein which retains its ability to interact with Scc1p, another component of the cohesin complex.
Title: The F658G substitution in Saccharomyces cerevisiae cohesin Irr1/Scc3 is semi-dominant in the diploid and disturbs mitosis, meiosis and the cell cycle.
IRR1-1 mutation in heterozygous state may influence the cell wall integrity and indicates a possible link between mechanisms regulating the cell wall biosynthesis, nuclear migration and chromosome segregation.
Title: Substitution F659G in the Irr1p/Scc3p cohesin influences the cell wall of Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromatin	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
part_of cohesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
part_of mitotic cohesin complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Irr1p

NP_012238.1

Subunit of the cohesin complex; which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms; relocalizes to the cytosol in response to hypoxia; essential for viability

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001141.2 Reference assembly

Range

304477..307929 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179376.1 → NP_012238.1 TPA: Irr1p [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012238.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VVQ4, P40541, Q02511

UniProtKB/TrEMBL

B3LTN3, C7GPX3, G2WGB9, N1P0M9

Conserved Domains (1) summary

COG5537
Location:74 → 881

IRR1; Cohesin [Cell division and chromosome partitioning]