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FAF1 Faf1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 854793, updated on 4-Jan-2025

Summary

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Official Symbol
FAF1
Official Full Name
Faf1p
Primary source
SGD:S000001281
Locus tag
YIL019W
See related
AllianceGenome:SGD:S000001281; FungiDB:YIL019W; VEuPathDB:YIL019W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See FAF1 in Genome Data Viewer
Location:
chromosome: IX
Exon count:
1
Sequence:
Chromosome: IX; NC_001141.2 (315093..316133)

Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase II core subunit RPB3 Neighboring gene 1-(5-phosphoribosyl)-5- ((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide isomerase HIS6 Neighboring gene ribosomal 60S subunit protein L2B Neighboring gene glucose-induced degradation complex subunit VID28

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001141.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ebp2p, the yeast homolog of Epstein-Barr virus nuclear antigen 1-binding protein 2, interacts with factors of both the 60 S and the 40 s ribosomal subunit assembly. Shirai C, et al. J Biol Chem, 2004 Jun 11. PMID 15078877
  2. Functional and physical interactions of Faf1p, a Saccharomyces cerevisiae nucleolar protein. Karkusiewicz I, et al. Biochem Biophys Res Commun, 2004 Jun 25. PMID 15178413
  3. Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast. Zheng S, et al. J Biol Chem, 2014 Aug 15. PMID 24990943, Free PMC Article
  4. Yeast Rrp14p is a nucleolar protein involved in both ribosome biogenesis and cell polarity. Yamada H, et al. RNA, 2007 Nov. PMID 17804645, Free PMC Article
  5. Cryo-EM structure of 90S small ribosomal subunit precursors in transition states. Du Y, et al. Science, 2020 Sep 18. PMID 32943522

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results illustrate the versatility of KH domains in protein interaction and provide insight into the role of Krr1-Faf1 interaction in ribosome biogenesis.
    Title: Interaction between ribosome assembly factors Krr1 and Faf1 is essential for formation of small ribosomal subunit in yeast.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Faf1p
NP_012245.1
  • Protein required for pre-rRNA processing; also required for 40S ribosomal subunit assembly

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001141.2 Reference assembly

    Range
    315093..316133
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179369.1 → NP_012245.1  TPA: Faf1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_012245.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VVR0, P40546, Q6Q5G5
    UniProtKB/TrEMBL
    A6ZVP8, B3LTM7, B5VKS2, C7GPW7, C8ZAN1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40546.1

Gene LinkOut

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