UFO1 SCF ubiquitin ligase complex subunit UFO1 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: UFO1
Official Full Name: SCF ubiquitin ligase complex subunit UFO1
Primary source: SGD:S000004553
Locus tag: YML088W
See related: AllianceGenome:SGD:S000004553; FungiDB:YML088W; VEuPathDB:YML088W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable protein-macromolecule adaptor activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in DNA damage response; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; and cellular response to methylmercury. Located in cytoplasm and nucleus. Part of SCF ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

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ubiquitin interacting motifs are crucial for Ufo1 ubiquitylation in vivo
Title: New interacting partners of the F-box protein Ufo1 of yeast.
a role for the protein Ddi1 in the turnover of the F-box protein, Ufo1
Title: Unique role for the UbL-UbA protein Ddi1 in turnover of SCFUfo1 complexes.
describes a unique E3, the F-box protein, Ufo1, of yeast; Ufo1 recruits the mating switch endonuclease, Ho, to the SCF complex for ubiquitylation
Title: The F-box protein, Ufo1, maintains genome stability by recruiting the yeast mating switch endonuclease, Ho, for rapid proteasome degradation.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein-macromolecule adaptor activity	ISA Inferred from Sequence Alignment more info	PubMed
contributes_to ubiquitin-protein transferase activity	ISA Inferred from Sequence Alignment more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA damage response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IPI Inferred from Physical Interaction more info	PubMed
involved_in cellular response to methylmercury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of SCF ubiquitin ligase complex	IDA Inferred from Direct Assay more info	PubMed
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

NP_013622.1

F-box receptor protein; subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitination by SCF and subsequent degradation