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DUS1 tRNA dihydrouridine synthase [ Saccharomyces cerevisiae S288C ]

Gene ID: 854895, updated on 9-Dec-2024

Summary

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Official Symbol
DUS1
Official Full Name
tRNA dihydrouridine synthase
Primary source
SGD:S000004545
Locus tag
YML080W
See related
AllianceGenome:SGD:S000004545; FungiDB:YML080W; VEuPathDB:YML080W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables tRNA dihydrouridine synthase activity. Involved in tRNA modification. Located in nucleus. Orthologous to human DUS1L (dihydrouridine synthase 1 like). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See DUS1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (108806..110077)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene F1F0 ATP synthase subunit i Neighboring gene Tda9p Neighboring gene Cff1p Neighboring gene peptidylprolyl isomerase CPR3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The specificities of four yeast dihydrouridine synthases for cytoplasmic tRNAs. Xing F, et al. J Biol Chem, 2004 Apr 23. PMID 14970222
  2. Rapid tRNA decay can result from lack of nonessential modifications. Alexandrov A, et al. Mol Cell, 2006 Jan 6. PMID 16387656
  3. Selective defects in gene expression control genome instability in yeast splicing mutants. Tam AS, et al. Mol Biol Cell, 2019 Jan 15. PMID 30462576, Free PMC Article
  4. Checkpoint kinase interaction with DNA polymerase alpha regulates replication progression during stress. Hadjicharalambous A, et al. Wellcome Open Res, 2023. PMID 37766847, Free PMC Article
  5. Comparative analysis of Saccharomyces cerevisiae WW domains and their interacting proteins. Hesselberth JR, et al. Genome Biol, 2006. PMID 16606443, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA dihydrouridine synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tRNA dihydrouridine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA dihydrouridine synthase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables tRNA-dihydrouridine16 synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-dihydrouridine17 synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA dihydrouridine synthesis IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA modification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tRNA modification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
tRNA dihydrouridine synthase
NP_013631.1
  • Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNAs at U16 and U17 of the D loop

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    108806..110077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182439.1 → NP_013631.1  TPA: tRNA dihydrouridine synthase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013631.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0K3, P53759
    UniProtKB/TrEMBL
    G2WJX5
    Conserved Domains (1) summary
    pfam01207
    Location:32 → 351
    Dus; Dihydrouridine synthase (Dus)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P53759.1

Gene LinkOut

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