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RPL6A ribosomal 60S subunit protein L6A [ Saccharomyces cerevisiae S288C ]

Gene ID: 854902, updated on 9-Dec-2024

Summary

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Official Symbol
RPL6A
Official Full Name
ribosomal 60S subunit protein L6A
Primary source
SGD:S000004538
Locus tag
YML073C
See related
AllianceGenome:SGD:S000004538; FungiDB:YML073C; VEuPathDB:YML073C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
YL16A
Summary
Enables RNA binding activity. A structural constituent of ribosome. Involved in cytoplasmic translation and ribosomal large subunit assembly. Part of cytosolic large ribosomal subunit. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See RPL6A in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
2
Sequence:
Chromosome: XIII; NC_001145.3 (123227..124172, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene hydroxymethylglutaryl-CoA reductase (NADPH) HMG1 Neighboring gene peptidylprolyl isomerase FPR3 Neighboring gene Tcb3p Neighboring gene Golgi transport complex subunit COG8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yeast ribosomal proteins: XIV. Complete nucleotide sequences of the two genes encoding Saccharomyces cerevisiae YL16. Hashimoto T, et al. Biochim Biophys Acta, 1992 Sep 24. PMID 1390890
  2. Protein synthesis rates and ribosome occupancies reveal determinants of translation elongation rates. Riba A, et al. Proc Natl Acad Sci U S A, 2019 Jul 23. PMID 31292258, Free PMC Article
  3. The Gcn4 transcription factor reduces protein synthesis capacity and extends yeast lifespan. Mittal N, et al. Nat Commun, 2017 Sep 6. PMID 28878244, Free PMC Article
  4. Depletion of Saccharomyces cerevisiae ribosomal protein L16 causes a decrease in 60S ribosomal subunits and formation of half-mer polyribosomes. Rotenberg MO, et al. Genes Dev, 1988 Feb. PMID 3282992
  5. Proximity of 5.8 S RNA-binding proteins and A-site proteins in yeast ribosomes inferred from cross-linking. Lee JC, et al. J Biol Chem, 1984 Aug 25. PMID 6432786

See all (117) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ribosomal large subunit assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribosomal 60S subunit protein L6A
NP_013638.1
  • Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    123227..124172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182432.1 → NP_013638.1  TPA: ribosomal 60S subunit protein L6A [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013638.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZA0, Q02326
    UniProtKB/TrEMBL
    A6ZLZ2, B3LLI3, C8ZED2, G2WJY2, N1NXW3
    Conserved Domains (1) summary
    cd13156
    Location:26 → 176
    KOW_RPL6; KOW motif of Ribosomal Protein L6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02326.2

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