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BUL2 ubiquitin-ubiquitin ligase BUL2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 854929, updated on 4-Jan-2025

Summary

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Official Symbol
BUL2
Official Full Name
ubiquitin-ubiquitin ligase BUL2
Primary source
SGD:S000004579
Locus tag
YML111W
See related
AllianceGenome:SGD:S000004579; FungiDB:YML111W; VEuPathDB:YML111W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin-ubiquitin ligase activity. Involved in protein monoubiquitination and protein polyubiquitination. Located in cytoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See BUL2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (46942..49704)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Dat1p Neighboring gene Ctk3p Neighboring gene 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase Neighboring gene Zds2p

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2. Watanabe D, et al. Biochem Biophys Res Commun, 2015 Jul 17-24. PMID 25998383
  2. The PY-motif of Bul1 protein is essential for growth of Saccharomyces cerevisiae under various stress conditions. Yashiroda H, et al. Gene, 1998 Dec 28. PMID 9931424
  3. Yeast Npi3/Bro1 is involved in ubiquitin-dependent control of permease trafficking. Springael JY, et al. FEBS Lett, 2002 Apr 24. PMID 12062418
  4. Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1. Soetens O, et al. J Biol Chem, 2001 Nov 23. PMID 11500494
  5. Rsp5-Bul1/2 complex is necessary for the HSE-mediated gene expression in budding yeast. Kaida D, et al. Biochem Biophys Res Commun, 2003 Jul 11. PMID 12821147

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in Rsp5p-Bul1-Bil2p ubiquitin ligase complex favors initial growth of autotrophic in synthetic grape must.
    Title: An impaired ubiquitin ligase complex favors initial growth of auxotrophic yeast strains in synthetic grape must.
  2. While rsp5(T255A), RSP5(T357A), and rsp5(T413A) impaired the interaction of Rsp5 with Bul1, the RSP5(T357A) mutation specifically augmented the interaction with Bul2.
    Title: Cooperative and selective roles of the WW domains of the yeast Nedd4-like ubiquitin ligase Rsp5 in the recognition of the arrestin-like adaptors Bul1 and Bul2.
  3. Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors.
    Title: Internal amino acids promote Gap1 permease ubiquitylation via TORC1/Npr1/14-3-3-dependent control of the Bul arrestin-like adaptors.
  4. Identification of a polymorphism in BUL2 in this outbred yeast population revealed a link among cellular amino acid availability, chronological lifespan, and telomere length control.
    Title: Natural polymorphism in BUL2 links cellular amino acid availability with chronological aging and telomere maintenance in yeast.
  5. Gln3-mediated transcription activated by nitrogen signal transduction is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae
    Title: Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin-ubiquitin ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-ubiquitin ligase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein monoubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein monoubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-ubiquitin ligase BUL2
NP_013596.1
  • Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex; ubiquitin-binding adaptor involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions; BUL2 has a paralog, BUL1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    46942..49704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182473.1 → NP_013596.1  TPA: ubiquitin-ubiquitin ligase BUL2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013596.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6W0H3, Q03758
    UniProtKB/TrEMBL
    A6ZLV3, B3LLE8, C7GV93, N1NYA8
    Conserved Domains (2) summary
    pfam04426
    Location:646 → 918
    Bul1_C; Bul1 C-terminus
    pfam04425
    Location:87 → 525
    Bul1_N; Bul1 N-terminus
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03758.1

Gene LinkOut

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