Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85496, updated on 4-Jan-2025

Summary

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Official Symbol: Enpp1provided by RGD
Official Full Name: ectonucleotide pyrophosphatase/phosphodiesterase 1provided by RGD
Primary source: RGD:628825
See related: EnsemblRapid:ENSRNOG00000013994 AllianceGenome:RGD:628825
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pc1; Npps
Summary: Enables phosphodiesterase I activity. Involved in several processes, including brain development; cellular response to cAMP; and cellular response to mechanical stimulus. Located in dendrite; neuronal cell body; and plasma membrane. Biomarker of aortic valve disease 1. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Biased expression in Kidney (RPKM 90.9), Liver (RPKM 89.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Enpp1 in Genome Data Viewer

Location:: 1p12

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (22518051..22583044)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (20698746..20763741)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (21748201..21813205)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats.
Title: ENPP1 downregulation and FGF23 upregulation in growth-related calcification of the tibial tuberosity in rats.
Increased NPP1 expression and activity might contribute to the decreased mineralisation observed when osteoblasts are exposed to acid conditions.
Title: Acidosis is a key regulator of osteoblast ecto-nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity.
Cyclic mechanical tension increases the expression of ENPP-1 in end-plate chondrocytes in a manner likely dependent on TGF-beta induction by the ERK1/2 signaling pathway.
Title: Expression of ectonucleotide pyrophosphatase-1 in end-plate chondrocytes with transforming growth factor beta 1 siRNA interference by cyclic mechanical tension.
The down-regulation of the ENPP-1 gene expression induced by intermittent cyclic mechanical tension is likely dependent on TGF-beta1 in end-plate chondrocytes of lumbar vertebrae.
Title: Intermittent cyclic mechanical tension-induced down-regulation of ectonucleotide pyrophosphatase phosphodiesterase 1 gene expression is mainly dependent on TGF-β1 in end-plate chondrocytes.
ecto-nucleotide pyrophosphatase/phosphodiesterase 1 and 3 are expressed on podocytes, but changes in expression of these enzymes are most likely not involved in etiology of insulin resistance in podocytes.
Title: Expression of membrane-bound NPP-type ecto-phosphodiesterases in rat podocytes cultured at normal and high glucose concentrations.
The expression of ENPP1, TNAP and ANK proteins could be detected in each generation of endplate chondrocytes. With the continuing passage of cells, the level of protein expression declined gradually.
Title: [Expression and significance of ENPP1, TNAP and ANK proteins in the degeneration of endplate chondrocytes in rats].
The effects of mechanical strain on the progressive ankylosis (ANK) gene and extracellular nucleotide phosphatase/phosphodiesterase (ENPP)1 mRNA expression and TGF-beta1 protein expression in rat endplate chondrocytes, were investigated.
Title: Effects of mechanical strain on ANK, ENPP1 and TGF-β1 expression in rat endplate chondrocytes in vitro.
these results indicate that intracellular cAMP levels regulate the expression of NPP1 in rat C6 glioma cells by a signalling pathway that is different from the GFAP signal transduction pathway
Title: Cyclic AMP-dependent down regulation of ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) in rat C6 glioma.
Forty SNPs in ALPL and 14 SNPs in ENPP1 genetic loci as well as pairwise haplotypes were tested for association with bone strength related traits.
Title: Association of ALPL and ENPP1 gene polymorphisms with bone strength related skeletal traits in a Chuvashian population.
An increase in the relative expression of NPP1 throughout the aging in all structures analyzed, except in hippocampus, where the higher expression has been detected in 14 days old rats.
Title: Expression mapping of ectonucleotide pyrophosphatase/phosphodiesterase 1-3 (E-NPP1-3) in different brain structures during rat development.

Submit: New GeneRIF Correction See all GeneRIFs (14)

General gene information

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Markers

d1rat153 (e-PCR)
- UniSTS:120295

AU048957 (e-PCR)
- UniSTS:145407

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info
enables 8-oxo-(d)RTP hydrolase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables ATP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables GTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables UTP diphosphatase activity	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cyclic-GMP-AMP hydrolase activity	ISO Inferred from Sequence Orthology more info
enables cyclic-GMP-AMP hydrolase activity	ISS Inferred from Sequence or Structural Similarity more info
enables dinucleotide phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dinucleotide phosphatase activity	ISO Inferred from Sequence Orthology more info
enables dinucleotide phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables exonuclease activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity, acting on ester bonds	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables insulin receptor binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables nucleoside triphosphate diphosphatase activity	ISO Inferred from Sequence Orthology more info
enables nucleoside triphosphate diphosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatase activity	ISO Inferred from Sequence Orthology more info
enables phosphodiesterase I activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphodiesterase I activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphodiesterase I activity	ISO Inferred from Sequence Orthology more info
enables phosphodiesterase I activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphoric diester hydrolase activity	ISO Inferred from Sequence Orthology more info
enables polysaccharide binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyrophosphatase activity	ISO Inferred from Sequence Orthology more info
enables scavenger receptor activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ATP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in B-1 B cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in adipose tissue development	ISO Inferred from Sequence Orthology more info
involved_in adult locomotory behavior	ISO Inferred from Sequence Orthology more info
involved_in adult walking behavior	ISO Inferred from Sequence Orthology more info
involved_in aorta development	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process involved in development	ISO Inferred from Sequence Orthology more info
involved_in artery development	ISO Inferred from Sequence Orthology more info
involved_in articular cartilage development	ISO Inferred from Sequence Orthology more info
involved_in axon regeneration	ISO Inferred from Sequence Orthology more info
involved_in biomineral tissue development	ISO Inferred from Sequence Orthology more info
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in bone growth	ISO Inferred from Sequence Orthology more info
acts_upstream_of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in bone mineralization involved in bone maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in bone remodeling	ISO Inferred from Sequence Orthology more info
involved_in bone resorption	ISO Inferred from Sequence Orthology more info
involved_in bone trabecula formation	ISO Inferred from Sequence Orthology more info
involved_in calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cartilage development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to acidic pH	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to insulin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to sodium phosphate	ISO Inferred from Sequence Orthology more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cementum mineralization	ISO Inferred from Sequence Orthology more info
involved_in central nervous system myelination	ISO Inferred from Sequence Orthology more info
involved_in cerebellum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in cerebral cortex development	IEP Inferred from Expression Pattern more info	PubMed
involved_in collagen-activated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in defense response to protozoan	ISO Inferred from Sequence Orthology more info
involved_in determination of adult lifespan	ISO Inferred from Sequence Orthology more info
involved_in diphosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in endochondral ossification	ISO Inferred from Sequence Orthology more info
involved_in establishment of localization in cell	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat pad development	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect gene expression	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in generation of precursor metabolites and energy	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell migration to bone marrow	ISO Inferred from Sequence Orthology more info
involved_in hippocampus development	IEP Inferred from Expression Pattern more info	PubMed
involved_in hormone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in inhibition of non-skeletal tissue mineralization	ISO Inferred from Sequence Orthology more info
involved_in inorganic diphosphate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in inorganic diphosphate transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in leukocyte activation involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in ligamentous ossification	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEP Inferred from Expression Pattern more info	PubMed
involved_in long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in macrophage differentiation	ISO Inferred from Sequence Orthology more info
involved_in magnesium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in melanocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in microglia differentiation	ISO Inferred from Sequence Orthology more info
involved_in microglial cell migration	ISO Inferred from Sequence Orthology more info
involved_in middle ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in mitochondrion organization	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in mucus secretion	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in muscle cell cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of D-glucose import	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fat cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycogen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hh target transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hh target transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein autophosphorylation	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in nucleoside triphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside triphosphate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in olfactory bulb development	IEP Inferred from Expression Pattern more info	PubMed
involved_in oligodendrocyte apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in organic phosphonate metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of ossification	ISO Inferred from Sequence Orthology more info
involved_in ossification	ISO Inferred from Sequence Orthology more info
involved_in osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in phosphate ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphate-containing compound metabolic process	ISO Inferred from Sequence Orthology more info
involved_in plasma cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within_negative_effect protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of bone mineralization	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ATP	ISO Inferred from Sequence Orthology more info
involved_in response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in response to dietary excess	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
involved_in response to magnesium ion	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to platelet-derived growth factor	ISO Inferred from Sequence Orthology more info
involved_in response to sodium phosphate	ISO Inferred from Sequence Orthology more info
involved_in response to vitamin B6	ISO Inferred from Sequence Orthology more info
involved_in response to wounding	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of temperature stimulus	ISO Inferred from Sequence Orthology more info
involved_in sequestering of triglyceride	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in spinal cord development	ISO Inferred from Sequence Orthology more info
involved_in striatum development	IEP Inferred from Expression Pattern more info	PubMed
involved_in tooth mineralization	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vitamin D3 metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in basal dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Names: E-NPP 1; NPPase; alkaline phosphodiesterase I; nucleotide diphosphatase; nucleotide pyrophosphatase; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein PC-1

NP_445987.2

EC 3.1.4.1

EC 3.6.1.9

XP_006227754.1

EC 3.1.4.1

EC 3.6.1.9

XP_038948891.1

EC 3.1.4.1

EC 3.6.1.9

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053535.2 → NP_445987.2 ectonucleotide pyrophosphatase/phosphodiesterase family member 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

Q91XQ3, Q920C8, Q924C3

UniProtKB/TrEMBL

A6JUK6, G3V7V4

Related

ENSRNOP00000019519.6, ENSRNOT00000019519.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

22518051..22583044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006227692.4 → XP_006227754.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X1

UniProtKB/Swiss-Prot

Q91XQ3, Q920C8, Q924C3

Conserved Domains (4) summary

smart00201
Location:86 → 126

SO; Somatomedin B -like domains

smart00477
Location:656 → 887

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:194 → 520

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase

cd16018
Location:192 → 560

Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
XM_039092963.2 → XP_038948891.1 ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform X2

UniProtKB/TrEMBL

A6JUK7

Conserved Domains (2) summary

smart00477
Location:305 → 536

NUC; DNA/RNA non-specific endonuclease

pfam01663
Location:3 → 168

Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase