NDC1 Ndc1p [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NDC1
Official Full Name: Ndc1p
Primary source: SGD:S000004493
Locus tag: YML031W
See related: AllianceGenome:SGD:S000004493; FungiDB:YML031W; VEuPathDB:YML031W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: A structural constituent of nuclear pore. Involved in nuclear pore organization and spindle pole body duplication. Located in nuclear envelope and spindle pole body. Part of nuclear pore transmembrane ring. Orthologous to human NDC1 (NDC1 transmembrane nucleoporin). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See NDC1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (214189..216156)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct domains in Ndc1 mediate its interaction with the Nup84 complex and the nuclear membrane.
Title: Distinct domains in Ndc1 mediate its interaction with the Nup84 complex and the nuclear membrane.
"remodels the structure of chromatin"(RSC) complex plays a role in distributing two spindle pole body (SPB) insertion factors, Nbp1 and Ndc1, to the new SPB. Thus, we provide insight into a role for a SWI/SNF family complex in SPB duplication and ploidy maintenance.
Title: The budding yeast RSC complex maintains ploidy by promoting spindle pole body insertion.
The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.
Title: The Saccharomyces cerevisiae spindle pole body (SPB) component Nbp1p is required for SPB membrane insertion and interacts with the integral membrane proteins Ndc1p and Mps2p.
Mps2-Bbp1 directly interacts with Mps3 and Ndc1. We then purified Spc29 and reconstituted the ternary Mps2-Bbp1-Spc29 complex, proving that Bbp1 can simultaneously interact with Mps2 and Spc29 and in this way link the central plaque of the spindle pole body to the nuclear envelope
Title: A ternary membrane protein complex anchors the spindle pole body in the nuclear envelope in budding yeast.
overexpression of NDC1, which is also required for nuclear pore complexes biogenesis, rescued both the spindle pole bodies and spindle pole bodies associated defects.
Title: Integrity and function of the Saccharomyces cerevisiae spindle pole body depends on connections between the membrane proteins Ndc1, Rtn1, and Yop1.
Ndc1 together with its interaction partners are collectively essential for the biosynthesis and structural integrity of yeast nuclear pore complex.
Title: Role of the Ndc1 interaction network in yeast nuclear pore complex assembly and maintenance.
The absence of Ndc1p results in aberrant nuclear pores that have enlarged diameters and lack proteinaceous material, leading to an increased diffusion between the cytoplasm and the nucleus.
Title: The role of the integral membrane nucleoporins Ndc1p and Pom152p in nuclear pore complex assembly and function.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables spindle pole body-nuclear membrane anchor activity	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of nuclear pore	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA transport	IEA Inferred from Electronic Annotation more info
involved_in nuclear pore organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear pore organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in nuclear pore organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in spindle pole body duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spindle pole body localization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
part_of nuclear pore	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore	IEA Inferred from Electronic Annotation more info
part_of nuclear pore transmembrane ring	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore transmembrane ring	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear pore transmembrane ring	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in spindle pole body	IBA Inferred from Biological aspect of Ancestor more info
located_in spindle pole body	IDA Inferred from Direct Assay more info	PubMed
located_in spindle pole body	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ndc1p

NP_013681.1

Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1