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TAF4 Taf4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855017, updated on 9-Dec-2024

Summary

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Official Symbol
TAF4
Official Full Name
Taf4p
Primary source
SGD:S000004607
Locus tag
YMR005W
See related
AllianceGenome:SGD:S000004607; FungiDB:YMR005W; VEuPathDB:YMR005W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
MPT1; TAF48; TSG2
Summary
Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and chromatin binding activity. Involved in transcription by RNA polymerase II. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in spermatogenic failure 13. Orthologous to human TAF4B (TATA-box binding protein associated factor 4b). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See TAF4 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (276045..277211)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Aim34p Neighboring gene Mvp1p Neighboring gene lysophospholipase Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells. Zhang Y, et al. Mol Cell, 2012 Oct 26. PMID 22959270, Free PMC Article
  2. Functional analysis of the TFIID-specific yeast TAF4 (yTAF(II)48) reveals an unexpected organization of its histone-fold domain. Thuault S, et al. J Biol Chem, 2002 Nov 22. PMID 12237303
  3. Molecular and genetic characterization of a Taf1p domain essential for yeast TFIID assembly. Singh MV, et al. Mol Cell Biol, 2004 Jun. PMID 15143185, Free PMC Article
  4. Intrinsic cooperativity potentiates parallel cis-regulatory evolution. Sorrells TR, et al. Elife, 2018 Sep 10. PMID 30198843, Free PMC Article
  5. A histone fold TAF octamer within the yeast TFIID transcriptional coactivator. Selleck W, et al. Nat Struct Biol, 2001 Aug. PMID 11473260

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Depletion or inactivation of Kin28 results in increased occupancy of Taf1 and Taf4 at promoters genome-wide.
    Title: Kin28 depletion increases association of TFIID subunits Taf1 and Taf4 with promoters in Saccharomyces cerevisiae.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Taf4p
NP_013718.1
  • TFIID subunit (48 kDa); involved in RNA polymerase II transcription initiation; potential Cdc28p substrate

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    276045..277211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182501.1 → NP_013718.1  TPA: Taf4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013718.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6ZM67, D6VZI0, P50105
    UniProtKB/TrEMBL
    G2WK57
    Conserved Domains (1) summary
    pfam05236
    Location:144 → 383
    TAF4; Transcription initiation factor TFIID component TAF4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P50105.1

Gene LinkOut

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