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PLB2 lysophospholipase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855018, updated on 9-Dec-2024

Summary

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Official Symbol
PLB2
Official Full Name
lysophospholipase
Primary source
SGD:S000004608
Locus tag
YMR006C
See related
AllianceGenome:SGD:S000004608; FungiDB:YMR006C; VEuPathDB:YMR006C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables lysophospholipase activity. Involved in glycerophospholipid metabolic process. Located in extracellular region and fungal-type cell wall. Orthologous to several human genes including PLA2G4C (phospholipase A2 group IVC); PLA2G4E (phospholipase A2 group IVE); and PLA2G4F (phospholipase A2 group IVF). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PLB2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (277561..279681, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mvp1p Neighboring gene Taf4p Neighboring gene uncharacterized protein Neighboring gene lysophospholipase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. Fyrst H, et al. Biochemistry, 1999 May 4. PMID 10231538
  2. Development and validation of a hydrophilic interaction liquid chromatography-tandem mass spectrometry method for the quantification of lipid-related extracellular metabolites in Saccharomyces cerevisiae. Sun T, et al. J Chromatogr B Analyt Technol Biomed Life Sci, 2012 May 15. PMID 22541168
  3. Ectopic expression of Arabidopsis phospholipase A genes elucidates role of phospholipase Bs in S. cerevisiae cells. Zhang M, et al. Open Microbiol J, 2009 Aug 13. PMID 19707290, Free PMC Article
  4. Regulation of activity in vitro and in vivo of three phospholipases B from Saccharomyces cerevisiae. Merkel O, et al. Biochem J, 2005 Apr 15. PMID 15588231, Free PMC Article
  5. Cloning of CnLYSO1, a novel extracellular lysophospholipase of the pathogenic fungus Cryptococcus neoformans. Coe JG, et al. Gene, 2003 Oct 16. PMID 14563553

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lysophospholipase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycerophospholipid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerophospholipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in fungal-type cell wall IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
lysophospholipase
NP_013719.1
  • Phospholipase B (lysophospholipase) involved in lipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    277561..279681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182502.1 → NP_013719.1  TPA: lysophospholipase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013719.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZI1, Q03674
    UniProtKB/TrEMBL
    A6ZM68, N1NYL0
    Conserved Domains (1) summary
    smart00022
    Location:17 → 582
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03674.1

Gene LinkOut

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