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HXT2 hexose transporter HXT2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 855023, updated on 9-Dec-2024

Summary

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Official Symbol
HXT2
Official Full Name
hexose transporter HXT2
Primary source
SGD:S000004613
Locus tag
YMR011W
See related
AllianceGenome:SGD:S000004613; FungiDB:YMR011W; VEuPathDB:YMR011W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables D-glucose transmembrane transporter activity and pentose transmembrane transporter activity. Involved in D-glucose transmembrane transport. Located in plasma membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6) and SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See HXT2 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (288079..289704)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene acireductone dioxygenase (Ni2+-requiring) Neighboring gene Any1p Neighboring gene tRNA-Glu Neighboring gene translation initiation factor 3 subunit CLU1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification by comprehensive chimeric analysis of a key residue responsible for high affinity glucose transport by yeast HXT2. Kasahara T, et al. J Biol Chem, 2007 May 4. PMID 17369259
  2. Transmembrane segment 10 is important for substrate recognition in Ga12 and Hxt2 sugar transporters in the yeast Saccharomyces cerevisiae. Kasahara M, et al. FEBS Lett, 1996 Jul 1. PMID 8766824
  3. Rapid kinetics of glucose uptake in Saccharomyces cerevisiae. Walsh MC, et al. Folia Microbiol (Praha), 1994. PMID 8550023
  4. The amino-terminal tail of Hxt11 confers membrane stability to the Hxt2 sugar transporter and improves xylose fermentation in the presence of acetic acid. Shin HY, et al. Biotechnol Bioeng, 2017 Sep. PMID 28464256, Free PMC Article
  5. Physiological characterization of putative high-affinity glucose transport protein Hxt2 of Saccharomyces cerevisiae by use of anti-synthetic peptide antibodies. Wendell DL, et al. J Bacteriol, 1993 Dec. PMID 8244939, Free PMC Article

See all (101) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The increased D-xylose affinity could be related to the C terminus, more specifically to a cysteine to proline mutation at position 505 in Hxt2.
    Title: Increased xylose affinity of Hxt2 through gene shuffling of hexose transporters in Saccharomyces cerevisiae.
  2. findings suggest that the general activity of RNAP III can indirectly affect the RNAP II transcriptional machinery on the HXT2 promoter when cellular perception transduced via the major signaling pathways, broadly recognized as on/off switch essential to either positive or negative HXT gene regulation, remain entirely intact
    Title: Low RNA Polymerase III activity results in up regulation of HXT2 glucose transporter independently of glucose signaling and despite changing environment.
  3. Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
    Title: Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters.
  4. In addition to leucine 201 (TM5), four residues of Hxt2 (leucine 59 and leucine 61 in TM1, asparagine 331 in TM7, and phenylalanine 366 in TM8) were found to be important for high affinity transport
    Title: Eight amino acid residues in transmembrane segments of yeast glucose transporter Hxt2 are required for high affinity transport.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables carbohydrate:proton symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fructose transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables mannose transmembrane transporter activity TAS
Traceable Author Statement
more info
 PubMed 
enables pentose transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in D-glucose transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in carbohydrate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fructose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in mannose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in pentose transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell periphery HDA PubMed 
located_in fungal-type vacuole HDA PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
hexose transporter HXT2
NP_013724.1
  • High-affinity glucose transporter of the major facilitator superfamily; expression is induced by low levels of glucose and repressed by high levels of glucose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    288079..289704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182507.1 → NP_013724.1  TPA: hexose transporter HXT2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZI5, P23585
    UniProtKB/TrEMBL
    A6ZM72, B3LLR2, B5VPD7, C7GLA8, C8ZEL7, E9P9G5, N1P5B7
    Conserved Domains (1) summary
    pfam00083
    Location:59 → 519
    Sugar_tr; Sugar (and other) transporter
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P23585.1

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