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UBX4 Ubx4p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855089, updated on 4-Jan-2025

Summary

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Official Symbol
UBX4
Official Full Name
Ubx4p
Primary source
SGD:S000004671
Locus tag
YMR067C
See related
AllianceGenome:SGD:S000004671; FungiDB:YMR067C; VEuPathDB:YMR067C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CUI1
Summary
Involved in ERAD pathway and sporulation resulting in formation of a cellular spore. Located in nucleus. Human ortholog(s) of this gene implicated in alveolar soft part sarcoma. Orthologous to human ASPSCR1 (ASPSCR1 tether for SLC2A4, UBX domain containing). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See UBX4 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (404323..405573, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Kar5p Neighboring gene Sov1p Neighboring gene Avo2p Neighboring gene N-terminal L-serine N(alpha)-acetyltransferase NatD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A comparative genomic approach for identifying synthetic lethal interactions in human cancer. Deshpande R, et al. Cancer Res, 2013 Oct 15. PMID 23980094, Free PMC Article
  2. Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum. Alberts SM, et al. J Biol Chem, 2009 Jun 12. PMID 19359248, Free PMC Article
  3. Binding of Cdc48p to a ubiquitin-related UBX domain from novel yeast proteins involved in intracellular proteolysis and sporulation. Decottignies A, et al. Yeast, 2004 Jan 30. PMID 14755638
  4. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response. De-Souza EA, et al. J Biol Chem, 2020 Mar 20. PMID 31996377, Free PMC Article
  5. Deviation of the typical AAA substrate-threading pore prevents fatal protein degradation in yeast Cdc48. Esaki M, et al. Sci Rep, 2017 Jul 14. PMID 28710470, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response.
    Title: The yeast protein Ubx4p contributes to mitochondrial respiration and lithium-galactose-mediated activation of the unfolded protein response.
  2. Cdc48-Ubx4 acts on the proteasome and uses the chaperone activity to promote its nuclear distribution, thereby optimizing the proteasome level for efficient degradation of mitotic regulators.
    Title: Cdc48 chaperone and adaptor Ubx4 distribute the proteasome in the nucleus for anaphase proteolysis.
  3. The observation that Ubx2 and Ubx4 are not found together in one complex with Cdc48 suggests several distinct steps in modulating the activity and localization of Cdc48 in endoplasmic reciculum
    Title: Ubx4 modulates cdc48 activity and influences degradation of misfolded proteins of the endoplasmic reticulum.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERAD pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ERAD pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sporulation resulting in formation of a cellular spore IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ubx4p
NP_013783.1
  • UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the role of the Cdc48p-Nplp-Ufd1p AAA ATPase complex in delivery of misfolded proteins to the proteasome; protein abundance increases in response to DNA replication stress; human ortholog ASPSCR1 partially complements the yeast null mutant

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    404323..405573 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182565.1 → NP_013783.1  TPA: Ubx4p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013783.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZP1, P54730
    UniProtKB/TrEMBL
    C7GL57, C8ZER9, N1NYP7
    Conserved Domains (2) summary
    smart00166
    Location:277 → 351
    UBX; Domain present in ubiquitin-regulatory proteins
    cd16105
    Location:4 → 74
    Ubl_ASPSCR1_like; Ubiquitin-like (Ubl) domain found at the N-terminus of mammalian ASPSCR1 (alveolar soft part sarcoma chromosomal region candidate gene 1 protein), Saccharomyces cerevisie Ubx4p, and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54730.1

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