U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PDS5 Pds5p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855099, updated on 9-Dec-2024

Summary

Go to the top of the page Help
Official Symbol
PDS5
Official Full Name
Pds5p
Primary source
SGD:S000004681
Locus tag
YMR076C
See related
AllianceGenome:SGD:S000004681; FungiDB:YMR076C; VEuPathDB:YMR076C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables structural molecule activity. Involved in DNA metabolic process; chromatin looping; and chromosome organization. Acts upstream of or within synaptonemal complex assembly. Located in condensed nuclear chromosome and cytosol. Part of meiotic recombination initiation complex. Orthologous to human PDS5A (PDS5 cohesin associated factor A) and PDS5B (PDS5 cohesin associated factor B). [provided by Alliance of Genome Resources, Dec 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PDS5 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (416196..420029, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Sdd2p Neighboring gene Rco1p Neighboring gene uncharacterized protein Neighboring gene tRNA-Val Neighboring gene ESCRT-III subunit protein VPS20

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mutation of the cohesin related gene PDS5 causes cell death with predominant apoptotic features in Saccharomyces cerevisiae during early meiosis. Ren Q, et al. Mutat Res, 2005 Mar 1. PMID 15708575
  2. Pds5 is required for homologue pairing and inhibits synapsis of sister chromatids during yeast meiosis. Jin H, et al. J Cell Biol, 2009 Sep 7. PMID 19736318, Free PMC Article
  3. Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae. Tong K, et al. PLoS One, 2014. PMID 24963665, Free PMC Article
  4. Meiotic prophase roles of Pds5 in recombination and chromosome condensation in budding yeast. Joo JH, et al. J Microbiol, 2022 Feb. PMID 35102525
  5. Budding yeast PDS5 plays an important role in meiosis and is required for sister chromatid cohesion. Zhang Z, et al. Mol Microbiol, 2005 May. PMID 15819623

See all (93) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit.
    Title: S. cerevisiae Cells Can Grow without the Pds5 Cohesin Subunit.
  2. Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops.
    Title: Smc3 acetylation, Pds5 and Scc2 control the translocase activity that establishes cohesin-dependent chromatin loops.
  3. ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
    Title: ESA1 regulates meiotic chromosome axis and crossover frequency via acetylating histone H4.
  4. PDS5A and PDS5B in Cohesin Function and Human Disease.
    Title: PDS5A and PDS5B in Cohesin Function and Human Disease.
  5. Pds5+Rec8] promotes double-strand break formation, maintains homolog bias for crossover formation and promotes S-phase progression.
    Title: Recruitment of Rec8, Pds5 and Rad61/Wapl to meiotic homolog pairing, recombination, axis formation and S-phase.
  6. the integrity of the Pds5-Scc1 interface is indispensable for the recruitment of Pds5 to cohesin, and that its abrogation results in loss of sister chromatid cohesion and cell viability.
    Title: Structure of the Pds5-Scc1 Complex and Implications for Cohesin Function.
  7. a novel role for Pds5 in Saccharomyces cerevisiae
    Title: Cohesin without cohesion: a novel role for Pds5 in Saccharomyces cerevisiae.
  8. propose that Pds5 maintains cohesion, at least in part, by antagonizing the polySUMO-dependent degradation of cohesin
    Title: Pds5 prevents the PolySUMO-dependent separation of sister chromatids.
  9. Data indicate that cell cycle protein Pds5 promotes acetylation of cohesin subunit Smc3 by acetyltransferase Eco1 during S phase.
    Title: Pds5 promotes and protects cohesin acetylation.
  10. Scc3 and Pds5 are cohesin maintenance factors required for cohesin ring stability or for maintaining its association with DNA.
    Title: Cohesin rings devoid of Scc3 and Pds5 maintain their stable association with the DNA.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables structural molecule activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homologous chromosome pairing at meiosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic DNA double-strand break formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic sister chromatid cohesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic sister chromatid cohesion IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of meiotic recombination initiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Pds5p
NP_013793.1
  • Cohesion maintenance factor; involved in sister chromatid condensation and cohesion; colocalizes with cohesin on chromosomes; performs its cohesin maintenance function in pre-anaphase cells by protecting the integrity of the cohesion complex; regulates homolog pairing and facilitates synaptonemal complex formation, axis formation, interhomolog recombination and synapsis during meiosis; relocalizes to the cytosol in response to hypoxia; scaffolding protein contains 26 HEAT repeats

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    416196..420029 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182575.1 → NP_013793.1  TPA: Pds5p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013793.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZQ0, Q04264, Q04780
    UniProtKB/TrEMBL
    C7GL48
    Conserved Domains (2) summary
    sd00044
    Location:276 → 308
    HEAT; HEAT repeat [structural motif]
    cd19953
    Location:28 → 680
    PDS5; Sister chromatid cohesion protein PDS5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04264.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous