SNO1 putative pyridoxal 5'-phosphate synthase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SNO1
Official Full Name: putative pyridoxal 5'-phosphate synthase
Primary source: SGD:S000004701
Locus tag: YMR095C
See related: AllianceGenome:SGD:S000004701; FungiDB:YMR095C; VEuPathDB:YMR095C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Contributes to glutaminase activity. Involved in 'de novo' pyridoxal 5'-phosphate biosynthetic process; negative regulation of apoptotic process; and pyridoxine biosynthetic process. Located in cytoplasm. Part of glutaminase complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See SNO1 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (457285..457959, complement)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The presence of a similar sequence was used to predict an antiapoptotic role for two yeast proteins, Sno1p and Fyv10p. Overexpression and knock-out experiments were used to validate this prediction.
Title: A TSC22-like motif defines a novel antiapoptotic protein family.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
contributes_to glutaminase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to glutaminase activity	IDA Inferred from Direct Assay more info	PubMed
enables glutaminase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in 'de novo' pyridoxal 5'-phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyridoxal phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyridoxal phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in pyridoxine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in pyridoxine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in vitamin B6 biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of glutaminase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of glutaminase complex	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: putative pyridoxal 5'-phosphate synthase

NP_013813.1

EC 3.5.1.2

EC 4.3.3.6

Protein of unconfirmed function; involved in pyridoxine metabolism; expression is induced during stationary phase; forms putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase; sno1-delta affects abundance of mRNA from downstream gene CTF13

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

457285..457959 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182595.1 → NP_013813.1 TPA: putative pyridoxal 5'-phosphate synthase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013813.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VZR8, Q03144

UniProtKB/TrEMBL

B3LLY6, B5VPM2, C7GL31, C8ZEU7, N1NYR7

Conserved Domains (1) summary

pfam01174
Location:18 → 223

SNO; SNO glutamine amidotransferase family