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HFD1 hexadecenal dehydrogenase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855137, updated on 4-Jan-2025

Summary

Official Symbol
HFD1
Official Full Name
hexadecenal dehydrogenase
Primary source
SGD:S000004716
Locus tag
YMR110C
See related
AllianceGenome:SGD:S000004716; FungiDB:YMR110C; VEuPathDB:YMR110C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables 4-hydroxybenzaldehyde dehydrogenase (NAD+) activity and carboxylate reductase activity. Involved in aldehyde catabolic process; sphingolipid metabolic process; and ubiquinone biosynthetic process from tyrosine. Located in lipid droplet and mitochondrial outer membrane. Used to study Sjogren-Larsson syndrome. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Orthologous to several human genes including ALDH3A1 (aldehyde dehydrogenase 3 family member A1); ALDH3A2 (aldehyde dehydrogenase 3 family member A2); and ALDH3B1 (aldehyde dehydrogenase 3 family member B1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See HFD1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (490394..491992, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene acetolactate synthase catalytic subunit Neighboring gene myosin 5 Neighboring gene Euc1p Neighboring gene Med11p

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by SGD

Process Evidence Code Pubs
involved_in aldehyde catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in aldehyde metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in aldehyde metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in aldehyde metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sphingolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ubiquinone biosynthetic process from tyrosine IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
hexadecenal dehydrogenase
NP_013828.1
  • Dehydrogenase involved in ubiquinone and sphingolipid metabolism; converts 4-hydroxybenzaldehyde into 4-hydroxybenzoate for ubiquinone anabolism, hexadecenal to hexadecenoic acid in sphingosine 1-phosphate catabolism; human homolog ALDH3A2, mutated in Sjogren-Larsson syndrome, can rescue yeast hfd1 mutant; human ALDH3A1, but not ALDH3A2, rescues pABA- respiratory growth phenotype of hfd1 null; data suggest that dual functions of Hfd1p have diverged in human ALDH3A1, ALDH3A2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    490394..491992 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182610.1NP_013828.1  TPA: hexadecenal dehydrogenase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013828.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZT3, Q04458
    UniProtKB/TrEMBL
    A6ZMG7, B3LM01, B5VPN5, C7GW99, C8ZEW3, G2WKG0, N1NYS7
    Conserved Domains (1) summary
    cl11961
    Location:11466
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily