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putative peptide hydrolase [ Saccharomyces cerevisiae S288C ]

Gene ID: 855141, updated on 9-Dec-2024

Summary

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Official Full Name
putative peptide hydrolase
Primary source
SGD:S000004720
Locus tag
YMR114C
See related
AllianceGenome:SGD:S000004720; FungiDB:YMR114C; VEuPathDB:YMR114C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Predicted to enable lyase activity; peptidase activity; and single-stranded DNA binding activity. Predicted to be involved in protein-DNA covalent cross-linking repair and proteolysis. Located in cytoplasm and nucleus. Orthologous to human HMCES (5-hydroxymethylcytosine binding, ES cell specific). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (496343..497449, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Med11p Neighboring gene dihydrofolate synthase Neighboring gene Mgr3p Neighboring gene ribosomal 40S subunit protein ASC1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple transcripts from a 3'-UTR reporter vary in sensitivity to nonsense-mediated mRNA decay in Saccharomyces cerevisiae. Zaborske JM, et al. PLoS One, 2013. PMID 24260526, Free PMC Article
  2. Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Fleischer TC, et al. Genes Dev, 2006 May 15. PMID 16702403, Free PMC Article
  3. A visual screen of protein localization during sporulation identifies new components of prospore membrane-associated complexes in budding yeast. Lam C, et al. Eukaryot Cell, 2014 Mar. PMID 24390141, Free PMC Article
  4. Network Rewiring of Homologous Recombination Enzymes during Mitotic Proliferation and Meiosis. Wild P, et al. Mol Cell, 2019 Aug 22. PMID 31351878, Free PMC Article
  5. Cross-linking Mass Spectrometry Analysis of the Yeast Nucleus Reveals Extensive Protein-Protein Interactions Not Detected by Systematic Two-Hybrid or Affinity Purification-Mass Spectrometry. Bartolec TK, et al. Anal Chem, 2020 Jan 21. PMID 31851481

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein-DNA covalent cross-linking repair IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm HDA PubMed 
located_in nucleus HDA PubMed 

General protein information

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Preferred Names
putative peptide hydrolase
NP_013832.1
  • hypothetical protein; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    496343..497449 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182614.1 → NP_013832.1  TPA: putative peptide hydrolase [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013832.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZT7, Q04471
    UniProtKB/TrEMBL
    A6ZMH1, B3LM05, C8ZEW7, N1P5K2
    Conserved Domains (1) summary
    pfam02586
    Location:1 → 239
    SRAP; SOS response associated peptidase (SRAP)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q04471.1

Gene LinkOut

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