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CEP3 Cep3p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855204, updated on 9-Dec-2024

Summary

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Official Symbol
CEP3
Official Full Name
Cep3p
Primary source
SGD:S000004778
Locus tag
YMR168C
See related
AllianceGenome:SGD:S000004778; FungiDB:YMR168C; VEuPathDB:YMR168C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
CBF3; CSL1
Summary
Enables DNA binding activity, bending and centromeric DNA binding activity. Involved in mitotic spindle assembly checkpoint signaling and septin ring assembly. Located in kinetochore. Part of CBF3 complex. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See CEP3 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (597332..599158, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Mme1p Neighboring gene mismatch repair ATPase MLH1 Neighboring gene aldehyde dehydrogenase (NAD(+)) ALD3 Neighboring gene aldehyde dehydrogenase (NAD(+)) ALD2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Microtubule-motor activity of a yeast centromere-binding protein complex. Hyman AA, et al. Nature, 1992 Oct 8. PMID 1406970
  2. A zinc finger protein, essential for chromosome segregation, constitutes a putative DNA binding subunit of the Saccharomyces cerevisiae kinetochore complex, Cbf3. Lechner J. EMBO J, 1994 Nov 1. PMID 7957085, Free PMC Article
  3. Factors required for the binding of reassembled yeast kinetochores to microtubules in vitro. Sorger PK, et al. J Cell Biol, 1994 Nov. PMID 7962081, Free PMC Article
  4. Probing the architecture of a simple kinetochore using DNA-protein crosslinking. Espelin CW, et al. J Cell Biol, 1997 Dec 15. PMID 9396745, Free PMC Article
  5. Insights from modeling the 3D structure of DNA-CBF3b complex. Chou KC. J Proteome Res, 2005 Sep-Oct. PMID 16212418

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the binding sites for Cbf1 and CEP3 (CBF3 subunit) are included within the centromeric nucleosome has important implications for models of the centromeric nucleosome and for kinetochore function.
    Title: The centromeric nucleosome of budding yeast is perfectly positioned and covers the entire centromere.
  2. The crystal structure of a large section of the protein Cep3 from CBF3, which is the only component with obvious DNA-binding motifs, was determined.
    Title: Insights into kinetochore-DNA interactions from the structure of Cep3Delta.
  3. the crystal structure, determined at 2.8 A resolution by multiple isomorphous replacement with anomalous scattering, of a truncated Cep3p
    Title: Crystal structure of the yeast inner kinetochore subunit Cep3p.
  4. Data show that the amino terminus of Sgt1p interacts with CBF3 subunits Skp1p and Ctf13p.
    Title: The interaction between Sgt1p and Skp1p is regulated by HSP90 chaperones and is required for proper CBF3 assembly.
  5. Three-dimensional structural model of the DNA-CBF3b complex. [CBF3B]
    Title: Insights from modeling the 3D structure of DNA-CBF3b complex.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding, bending IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables centromeric DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
Process Evidence Code Pubs
involved_in mitotic spindle assembly checkpoint signaling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in septin ring assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CBF3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in kinetochore IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cep3p
NP_013891.1
  • Essential kinetochore protein; component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    597332..599158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182672.1 → NP_013891.1  TPA: Cep3p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013891.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZZ0, P40969
    UniProtKB/TrEMBL
    B3LM55, C7GU54, C8ZF28, N1P0F3
    Conserved Domains (2) summary
    cd12147
    Location:55 → 606
    Cep3_C; C-terminal domain of the Cep3, a subunit of the yeast centromere-binding factor 3
    pfam00172
    Location:12 → 48
    Zn_clus; Fungal Zn(2)-Cys(6) binuclear cluster domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40969.1

Gene LinkOut

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