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EAR1 Ear1p [ Saccharomyces cerevisiae S288C ]

Gene ID: 855207, updated on 9-Dec-2024

Summary

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Official Symbol
EAR1
Official Full Name
Ear1p
Primary source
SGD:S000004781
Locus tag
YMR171C
See related
AllianceGenome:SGD:S000004781; FungiDB:YMR171C; VEuPathDB:YMR171C
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary
Enables ubiquitin-like ligase-substrate adaptor activity. Involved in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in endosome. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See EAR1 in Genome Data Viewer
Location:
chromosome: XIII
Exon count:
1
Sequence:
Chromosome: XIII; NC_001145.3 (603868..605520, complement)

Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene aldehyde dehydrogenase (NAD(+)) ALD3 Neighboring gene aldehyde dehydrogenase (NAD(+)) ALD2 Neighboring gene Hot1p Neighboring gene DNA damage-responsive protein 48

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies. Léon S, et al. Mol Biol Cell, 2008 Jun. PMID 18367543, Free PMC Article
  2. Localization of a subset of yeast mRNAs depends on inheritance of endoplasmic reticulum. Fundakowski J, et al. Traffic, 2012 Dec. PMID 22994588
  3. Retrograde trafficking and quality control of yeast synaptobrevin, Snc1, are conferred by its transmembrane domain. Ma M, et al. Mol Biol Cell, 2019 Jul 1. PMID 31067149, Free PMC Article
  4. Rsp5 Ubiquitin ligase-mediated quality control system clears membrane proteins mistargeted to the vacuole membrane. Sardana R, et al. J Cell Biol, 2019 Jan 7. PMID 30361468, Free PMC Article
  5. Use of a wine yeast deletion collection reveals genes that influence fermentation performance under low-nitrogen conditions. Peter JJ, et al. FEMS Yeast Res, 2018 May 1. PMID 29425293

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ear1p/Ssh4p recruit Rsp5p and assist it in its function at multivesicular bodies by directing the ubiquitylation of specific cargoes.
    Title: Ear1p and Ssh4p are new adaptors of the ubiquitin ligase Rsp5p for cargo ubiquitylation and sorting at multivesicular bodies.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum HDA PubMed 
located_in endosome HDA PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  
located_in vacuole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ear1p
NP_013894.1
  • Specificity factor required for Rsp5p-dependent ubiquitination; also required for sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001145.3 Reference assembly

    Range
    603868..605520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001182675.1 → NP_013894.1  TPA: Ear1p [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_013894.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D6VZZ3, Q03212, Q03830
    UniProtKB/TrEMBL
    A6ZMN0, C7GSR7, N1NXG9
    Conserved Domains (1) summary
    cd12910
    Location:185 → 374
    SPRY_SSH4_like; SPRY domain in SSH4 and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03212.1

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